Overview

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging.

Full Product Details

Author:   Karoly Vekey (Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary) ,  Andreas Telekes (National Oncology Institute, Budapest, Hungary) ,  Akos Vertes (W.M. Keck Institute for Proteomics Technology & Applications, Washington DC, U.S.A.)
Publisher:   Elsevier Science & Technology
Imprint:   Elsevier Science Ltd
Dimensions:   Width: 16.50cm , Height: 3.00cm , Length: 24.00cm
Weight:   1.210kg
ISBN:  

9780444519801

ISBN 10:   0444519807
Pages:   606
Publication Date:   16 October 2007
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

1. Introduction 2. Basics of analytical chemistry and mass spectrometry for medical professionals 3. Ethical, legal, safety and scientific aspects of medical research 4. Biomedical sampling 5. Separation methods 6. Mass spectrometry instrumentation and techniques 7. Cheminformatics: multivariate mathematical-statistical methods for data evaluation 8. Mass spectrometry in proteomics 9. De novo sequencing of peptides 10. Protein bioinformatics 11. Analysis of complex lipidomes 12. Medical laboratory practice - possibilities for mass spectrometry 13. Therapeutic drug monitoring 14. Mass spectrometry of infectious pathogens 15. Proteomics of viruses and their host partners 16. Neonatal diagnostics 17. Application of mass spectrometry in oncology 18 Application of mass spectrometry in brain research: neurotransmitters, neuropeptides and brain proteins 19. The human pituitary proteome: clinical applications 20. Mass spectrometry of proteinous allergens inducing human diseases 21. Mass spectrometry in clinical treatment 22. Biomarker discovery 23. Molecular imaging by mass spectrometry 24. Brief outlook

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Author Information

Professor of Chemistry, Professor of Biochemistry and Molecular Biology. Founder and Co-director, Institute for Proteomics Technology and Applications, The George Washington University.

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