Overview

Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies. This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.

Full Product Details

Author:   Sudhir Gupta
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 2001
Volume:   490
Dimensions:   Width: 15.50cm , Height: 0.80cm , Length: 23.50cm
Weight:   0.238kg
ISBN:  

9781461354581

ISBN 10:   1461354587
Pages:   136
Publication Date:   25 September 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Basic Mechanisms.- Delineation of the Pathogenesis of Systemic Lupus Erythematosus by Using Murine Models.- Factors Contributing to Autoimmune Disease.- Control of Autoimmunity by Regulatory T Cells.- Autoimmunity, Self-Tolerance, and Immune Homeostasis: From Whole Animal Phenotypes to Molecular Pathways.- Peripheral Tolerance and Organ Specific Autoimmunity.- Autoimmune Lymphoproliferative Syndrome: Types I, II, and Beyond.- Pathogenesis.- The Role of MHC Class II Molecules in the Pathogenesis and Prevention of Type I Diabetes.- Control of Autoreactive T Cell Activation by Immunoregulatory T Cells.- Immune Tolerance and The Nervous System.- Functional Role of Epitope Spreading in the Chronic Pathogenesis of Autoimmune and Virus-Induced Demyelinating Diseases.- Therapy.- Multiple Sclerosis and Gene Expression Profiling.- Treatment of Autoimmunity by Inhibition of T Cell Costimulation.- Cytokine Blockade in Rheumatoid Arthritis.

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