Overview

During the last decade, rapid progress has been made in the area of microbial immu- nity. New conceptual frameworks have emerged with regard to the processing and presen- tation of peptides and nonpeptide antigens from microbes, especially bacteria, to T cells in the context of classical MHC class I and nonconventional MHC I molecules. Experimen- tal models have been instrumental in defining some of these pathways for generating pro- tective immune responses against microbes, which form the basis for the design of new vaccines. New evidence has stressed the importance of innate immunity in microbial in- fections. The concept of dichotomy within T helper cells has revealed the role of these cell types in resistance and susceptibility to microbial-mediated pathology. These latest devel- opments in microbial immunity are discussed in this volume. Natural killer cell development is known to be regulated by the presence of MHC class I antigens. Receptors for MHC class I molecules on NK cells have been discovered. Interaction of these receptors with their specific ligands leads to inhibition of cytotoxicity. Vinay Kumar and colleagues review NK cell differentiation and ontogeny, and functions of NK cells in experimental animals. Lewis Lanier discusses the role of a newly discov- ered molecule, DAP 12, in KIR and other receptor-mediated signal transduction in NK cells. Eric Long describes the regulation of immune response by inhibitory receptors.

Full Product Details

Author:   Sudhir Gupta ,  Alan Sher ,  Rafi Ahmed
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1998
Volume:   452
Dimensions:   Width: 17.00cm , Height: 1.20cm , Length: 24.40cm
Weight:   0.422kg
ISBN:  

9781461374435

ISBN 10:   146137443
Pages:   223
Publication Date:   23 October 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Development of Self-Recognition Systems in Natural Killer Cells.- 2. Activating and Inhibitory NK Cell Receptors.- 3. Regulation of Immune Responses by Inhibitory Receptors.- 4. Innate Functions of Epithelial ?? T Cells.- 5. Interleukin-4 Receptor Signalling Mechanisms and Their Biological Significance.- 6. Development of CD4+ Effector T Cells and Susceptibility to Infectious Diseases.- 7. Anti-Leishmania Effector Functions of CD4+ Th1 Cells and Early Events Instructing Th2 Cell Development and Susceptibility to Leishmania major in BALB/c Mice.- 8. Genetic Control of the T Cell Response to Leishmania major Infection.- 9. The Initiation and Function of Th2 Responses during Infection with Schistosoma mansoni.- 10. Interleukin-4 Production in Response to Infection with Intracellular Bacteria.- 11. Cytotoxic T Lymphocytes in Resistance to Tuberculosis.- 12. The Role of Dendritic Cells in the Initiation of Host Resistance to Toxoplasma gondii.- 13. Dynamics of the CD8+ T Cell Response during Acute LCMV Infection.- 14. In Vivo Dynamics of Anti-Viral CD8 T Cell Responses to Different Epitopes: An Evaluation of Bystander Activation in Primary and Secondary Responses to Viral Infection.- 15. Early Cytokine Responses to Viral Infections and Their Roles in Shaping Endogenous Cellular Immunity.- 16. HIV Entry and Tropism: When One Receptor Is Not Enough.- 17. Immune Control of HIV-1 Replication.- 18. HIV Transmission and Immune Protection at Mucosal Surfaces.- 19. The CD8+ T Lymphocyte Response during Primary SIVmac Infection.- 20. Non-Structural Determinants of Immunogenicity and the B Cell Co-Receptors, CD19, CD21, and CD22.- 21. DNA Vaccines: Mechanisms for Generation of Immune Responses.- 22. Vaccines against the Blood Stages of Falciparum Malaria.- 23. Immunity toPertussis: Not All Virulence Factors Are Protective Antigens.

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