Overview

The induction of blood vessel growth as part of an adaptive process can be either exaggerated, such as in tumors, or too slow, as in ischemic diseases of heart and brain. Therefore it is an interesting target for medical intervention. This volume presents a thorough reconsideration of our current knowledge of factors and principles involved in angiogenic processes. It proceeds from a ""macroscopic "" perspective through cellular and physical mechanisms to the molecular level . In the first part, angiogenesis in physiological as well as pathological processes is described with a focus on embryogenesis, the reproductive system and the growing heart. The second part deals with cellular and physical mechanisms leading to angiogenesis, and the last part presents a deeper insight into molecular mechanisms of blood vessel growth, including knockout studies of essential angiogenic molecules, the identification of signaling steps in angiogenesis and the importance of cellular junctions.

Full Product Details

Author:   Matthias Clauss ,  Georg Breier
Publisher:   Birkhauser Verlag AG
Imprint:   Birkhauser Verlag AG
Edition:   2005 ed.
Volume:   94
Dimensions:   Width: 17.00cm , Height: 2.30cm , Length: 24.40cm
Weight:   0.769kg
ISBN:  

9783764364595

ISBN 10:   3764364599
Pages:   324
Publication Date:   22 November 2004
Audience:   General/trade ,  Professional and scholarly ,  General ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Basic principles in physiological and pathophysiological angiogenesis.- How do endothelial cells orientate?.- New insights into intussusceptive angiogenesis.- Angiogenesis in the female reproductive system.- Arterialization, coronariogenesis and arteriogenesis.- Sprouting angiogenesis versus co-option in tumor angiogenesis.- Hormones and the neovascularization process: role of angiotensin II.- Can tumor angiogenesis be inhibited without resistance?.- Cellular and physical mechanisms of blood vessel growth.- Role of pericytes in vascular morphogenesis.- Role of monocytes and macrophages in angiogenesis.- Bone marrow-derived endothelial progenitor cells for neovascular formation.- Can angiogenesis be exercised?.- Angiogenesis — a self-adapting principle in hypoxia.- Cellular mechanisms of arteriogenesis.- Balancing luminal size and smooth muscle proliferation — a key control point in atherosclerosis and arteriogenesis.- Molecular mechanisms of angiogenesis.- The role of VEGF in the regulation of physiological and pathological angiogenesis.- The anti-inflammatory actions of angiopoietin-1.- The hemostatic system in angiogenesis.- Signal transduction in angiogenesis.

Reviews

Author Information

Tab Content 6

Author Website:  

Countries Available

All regions