Overview

A large proportion of cancers is preventable. External factors, discovered by epidemiological studies during the last 50 years, account for a majority of all cancer deaths. However, still rather little is known, about how environmental and genetic factors interact, how they may regulate gene activation etc. And it is a long way from the discovery of a basic regulatory mechanism to practical patient treatment. This volume describes the present state of the art in carcinogenesis, possibilities for cancer prevention, and gives genetic background in cancer development. Attention is given to the host-environment interaction, considering how this interaction may lead to cancer formation and how it can be utilised in cancer prevention. The molecular basis for cancer development and the molecular basis for prevention are described.

Full Product Details

Author:   Harri U. Vainio ,  Eino K. Hietanen
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 2003
Volume:   156
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   0.539kg
ISBN:  

9783642078590

ISBN 10:   3642078591
Pages:   329
Publication Date:   01 December 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Causes of Cancer and Opportunities for Prevention.- 2 Genetic and Environmental Factors in Carcinogenesis.- 3 Genetic Pathways to Human Cancer.- 4 Signalling Pathways as Targets in Cancer Prevention.- 5 TP53 in Carcinogenesis and Cancer Prevention.- 6 Apoptosis.- 7 Deficient DNA Mismatch Repair in Carcinogenesis.- 8 Epigenetic Changes, Altered DNA Methylation and Cancer.- 9 Hormonal Carcinogenesis.- 10 Angiogenesis: A Promising Target for Cancer Prevention.- 11 Arachidonic Acid Pathway in Cancer Prevention.- 12 Infections, Inflammation and Cancer: Roles of Reactive Oxygen and Nitrogen Species.- 13 Infections and the Etiology of Human Cancer: Epidemiological Evidence and Opportunities for Prevention.- 14 Xenobiotic Metabolism and Cancer Susceptibility.- 15 Animal Models for Mechanistic Cancer Research.- 16 New Promising Chemopreventive Agents and Mechanisms.- 17 Molecular Epidemiology in Cancer Prevention.

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