Overview

This exciting book brings together an international and interdisciplinary group of experts to discuss the importance of pulsatile signalling in the induction of biological responses. Coverage includes the basic mechanisms involved in hormone pulsatility, the significance of pulsatility in normal and disease conditions, the relevance of circadian rhythms, changes with ageing, and detailed consideration of specific peptide hormone systems. This book includes contributions from professionals working in both basic and clinical research and reveals much new and exciting work in this area and promises new research directions.

Full Product Details

Author:   Derek J. Chadwick ,  Jamie A. Goode
Publisher:   John Wiley & Sons Inc
Imprint:   John Wiley & Sons Inc
Volume:   No. 227
Dimensions:   Width: 15.80cm , Height: 1.80cm , Length: 23.60cm
Weight:   0.572kg
ISBN:  

9780471999188

ISBN 10:   0471999180
Pages:   288
Publication Date:   26 January 2000
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Introduction (J. Veldhuis). Rhythmic Transcription: The Molecular Basis of Oscillatory Melatonin Synthesis (N. Foulkes, et al.). The Frequency Encoding of Pulsatility (A. Goldbeter, et al.). Timing-Dependent Modulation of Insulin Mitogenic Versus Metabolic Signalling (P. De Meyts & R. Shymko). Growth Hormone Pulse-Activated STAT5 Signalling: A Unique Regulatory Mechanism Governing Sexual Dimorphism of Liver Gene Expression (D. Waxman). Orderliness of Hormone Release (S. Pincus). Prediction and Significance of the Temporal Pattern of Hormone Secretion in Disease States (G. Brabant & K. Prank). Therapeutic Implications of Circadian Rhythms in Cancer Patients (F. Lévi). Pathophysiology of Human Circadian Rhythms (G. Copinschi, et al.). Nature of Altered Pulsatile Hormone Release and Neuroendocrine Network Signalling in Human Ageing: Clinical Studies of the Somatotropic, Gonadotropic, Corticotropic and Insulin Axes (J. Veldhuis). Pulsatile Insulin Secretion (P. Butler). Control of Growth Hormone (GH) release by GH Secretagogues (I. Robinson). Pulsatile Parathyroid Hormone Secretion in Health and Disease (F. Schaefer). Significance of Pulsatility in the HPA Axis (S. Lightman, et al.). Closing Remarks (J. Veldhuis). Indexes.

Reviews

"""This book provides a comprehensive and excellent summary of our state of knowledge,"" (Cell Biology International, May 2001) ""This outstanding text should stimulate further research on pulsatile hormone secretion that will enhance both biomedical science and clinical treatments of hormone-related disorders"" (Trends in Endocrinology & Metabolism, August 2001)"

This book provides a comprehensive and excellent summary of our state of knowledge, (Cell Biology International, May 2001) This outstanding text should stimulate further research on pulsatile hormone secretion that will enhance both biomedical science and clinical treatments of hormone-related disorders (Trends in Endocrinology & Metabolism, August 2001)

This book provides a comprehensive and excellent summary of our state of knowledge, (Cell Biology International, May 2001) This outstanding text should stimulate further research on pulsatile hormone secretion that will enhance both biomedical science and clinical treatments of hormone-related disorders (Trends in Endocrinology & Metabolism, August 2001)

Author Information

Derek J. Chadwick and Jamie A. Goode are editors for Mechanisms and Biological Significance of Pulsatile Hormone Secretion and other scientific titles.

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