Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy

Author:   Raouf A Khalil (Division of Vascular Surgery, Brigham and Women's Hospital, Boston, MA, USA)
Publisher:   Elsevier Science Publishing Co Inc
Volume:   148
ISBN:  

9780128127766


Pages:   446
Publication Date:   26 June 2017
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

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Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy


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Author:   Raouf A Khalil (Division of Vascular Surgery, Brigham and Women's Hospital, Boston, MA, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   148
Weight:   0.910kg
ISBN:  

9780128127766


ISBN 10:   0128127767
Pages:   446
Publication Date:   26 June 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. The Role of Matrix Metalloproteinases in Development, Repair, and Destruction of the Lungs Amanda Y. Hendrix and Farrah Kheradmand 2. Matrix Metalloproteinases in Kidney Disease: Role in Pathogenesis and Potential as a Therapeutic Target Alan R. Parrish 3. Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy Renu A. Kowluru and Manish Mishra 4. Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia Juanjuan Chen and Raouf A. Khalil 5. Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology Ciro De Luca and Michele Papa 6. Matrix Metalloproteinases in Bone Resorption, Remodeling, and Repair Katiucia B.S. Paiva and José M. Granjeiro 7. Matrix Metalloproteinases and Synovial Joint Pathology Charles J. Malemud 9. Metalloproteinases in Rheumatoid Arthritis: Potential Therapeutic Targets to Improve Current Therapies Yoshifumi Itoh 9. The Roles of Matrix Metalloproteinases in Pancreatic Cancer Anna M. Knapinska, Christie-Anne Estrada and Gregg B. Fields 10. Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders Jie Liu and Raouf A. Khalil

Reviews

Praise for the Series: Maintains the tradition and set-up of the previous volumes and certainly provides up-to-date data on varied aspects of cytology... a valuable acquisition to any library. --The Nucleus


"Praise for the Series: ""Maintains the tradition and set-up of the previous volumes and certainly provides up-to-date data on varied aspects of cytology... a valuable acquisition to any library."" --The Nucleus"


"Praise for the Series: ""Maintains the tradition and set-up of the previous volumes and certainly provides up-to-date data on varied aspects of cytology... a valuable acquisition to any library."" --The Nucleus"


Author Information

Dr. Raouf Khalil is an MD PhD who is very interested in scientific research. After receiving his MD, he joined the graduate school and received his PhD in Pharmacology from the University of Miami, Florida. After doing postdoctoral training at Harvard University, he joined the faculty at University of Mississippi Medical Center. He then moved back to Harvard where he is now Associate Professor at Harvard Medical School and the Brigham and Women's Hospital, Boston, Massachusetts, USA. Dr. Khalil has long been interested in vascular physiology and cell biology. The main focus of his research laboratory is to study the cellular mechanisms of vascular tone under physiological conditions and the changes in these mechanisms in pathological conditions such as coronary artery disease, salt-sensitive hypertension, hypertension in pregnancy, preeclampsia, pulmonary hypertension, and chronic venous disease. State-of-the-art equipment to study various aspects of the vascular system at the whole animal, tissue, cellular, and molecular level are available in his laboratory. Powerful techniques such as physiological bioassays, radioimmunoassays, mRNA and protein analysis, cell and organ culture, immunofluorescence, digital imaging and confocal microscopy are also available. Dr. Khalil's research projects include investigation of endothelium-dependent mechanisms of vascular relaxation, calcium-dependent and calcium-independent mechanisms of vascular and uterine contraction, role of protein kinases and phosphatases in vascular and uterine smooth muscle contraction, mechanisms of sex differences in vascular tone, the role of endothelin in salt-sensitive hypertension, and the role of matrix metalloproteinases in hypertension in pregnancy, preeclampsia, pulmonary hypertension, and chronic venous disease.

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