Overview

The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.

Full Product Details

Author:   Robert P. Mecham (Washington University, St. Louis, Missouri, U.S.A.) ,  William C. Parks (Washington University, St. Louis, Missouri, U.S.A.)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 15.20cm , Height: 2.10cm , Length: 22.90cm
Weight:   0.680kg
ISBN:  

9780125450904

ISBN 10:   0125450907
Pages:   362
Publication Date:   27 March 1998
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Contributors. Preface. The Matrix Metalloproteinase Family, J.F. Woessner, Jr.. Interstitial Collagenases, J.J. Jeffrey. Stromelysins 1 and 2, H. Nagase. 72-kDa Gelatinase (Gelatinase A): Structure, Activation, Regulation, and Substrate Specificity, A.E. Yu, A.N. Murphy and W.G. Stetler-Stevenson. Gelatinase B: Structure, Regulation, and Function, T.H. Vu and Z. Werb. Matrilysin, C.L. Wilson and L.M. Matrisian. Macrophage Elastase (MMP-12), S.D. Shapiro and R.M. Senior. Membrane-Type Matrix Metalloproteinases and Cell Surface-Associated Activation Cascades for Matrix Metalloproteinases, V. Knauper and G. Murphy. Substrate Specificity and Mechanism of Substrate Recognition of the Matrix Metalloproteinases, V. Imper and H.E. Van Wart. Synthetic Inhibitors of Matrix Metalloproteinases, P.D. Brown. Matrix Metalloproteinases in Tissue Repair, W.C. Parks, B.D. Sudbeck, G.R. Doyle and U.K. Saariahlo-Kere. Regulation of Matrix Metalloproteinase Gene Expression, M.E. Fini, J.R. Cook, R. Mohan and C.E. Brinckerhoff. Index.

Reviews

It is an encyclopedia and up-to-date compendium of the minute details of the literature on all characterized MMPs for specialists in this field... would I buy it? Yes. --CELL In all, this book is a very comprehensive coverage of the specialized area of MMPs. The editors and contributors describe not only the current status of research being conducted in this field, but also speculate on the future direction of that research. --DOODY'S PUBLISHING REVIEWS

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