Matrix Metalloproteinase Inhibitors in Cancer Therapy
Author:   Neil J. Clendeninn ,  Krzysztof Appelt
Publisher:   Humana Press Inc.
Edition:   2001 ed.
ISBN:  

9780896036680


Pages:   262
Publication Date:   17 September 2000
Format:   Hardback
Availability:   Out of stock   Availability explained
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Matrix Metalloproteinase Inhibitors in Cancer Therapy


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Overview

Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors in Cancer Therapy offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.

Full Product Details

Author:   Neil J. Clendeninn ,  Krzysztof Appelt
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2001 ed.
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   0.639kg
ISBN:  

9780896036680


ISBN 10:   0896036685
Pages:   262
Publication Date:   17 September 2000
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock   Availability explained
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

1 Biology and Regulation of the Matrix Metalloproteinases.- 2 Substrate Specificity of MMPs.- 3 The Tissue Inhibitors of Metalloproteinases (TIMPs): Biology and Regulation.- 4 Matrix Metalloproteinases in Cancer.- 5 Hydroxamic Acid Matrix Metalloproteinase Inhibitors.- 6 Prinomastat: A Potent and Selective Matrix Metalloprotease Inhibitor—Preclinical and Clinical Development for Oncology.- 7 A Potent Nonpeptidic Matrix Metalloproteinase Inhibitor: Discovery of BAY 12-9566.- 8 D1927 and D2163: Novel Mercaptoamide Inhibitors of Matrix Metalloproteinases.- 9 Research on MMP Inhibitors with Unusual Scaffolds.- 10 Matrix Metalloproteinase Inhibitors: Therapeutic Applications Outside of Oncology.

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