Overview

The discovery of IgE and its association with mast cell histamine release provided the initial understanding of the role of mast cells in asthma and acute allergic reactions. However, mast cells are now recognized as tissue-dwelling effector cells that play multiple roles not only in immediate-type allergic reaction but also in innate immunity, inflammation, angiogenesis, and tissue remodeling. Mast cells produce a variety of lipid mediators, chemokines, cytokines, and enzymes that may interact with inflammatory tissues such as asthmatic lungs. This book focuses on the roles of mast cell products in allergic diseases and discusses strategies to regulate mast cell functions without perturbing their physiological roles. It also aims at understanding mast cells at the system level by creating a detailed model of cell regulation which is expected to lead to highly mast cell-specific, i.e. efficient and safe, drug targets. Allergologists, immunologists and pharmacologists interested in developing new drugs for allergies will benefit from these timely reviews.

Full Product Details

Author:   H. Saito ,  Y. Okayama ,  T.A.E. Platts-Mills ,  Johannes Ring
Publisher:   S Karger AG
Imprint:   S Karger AG
Volume:   87
Dimensions:   Width: 17.50cm , Height: 1.40cm , Length: 24.50cm
Weight:   0.620kg
ISBN:  

9783805579483

ISBN 10:   3805579489
Pages:   218
Publication Date:   27 June 2005
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Awaiting stock  
The supplier is currently out of stock of this item. It will be ordered for you and placed on backorder. Once it does come back in stock, we will ship it out for you.

Table of Contents

Preface: Saito, H; Regulation of Mast Cell Development: Shiohara, M.; Koike, K; Regulation of Mast Cell Activation through Fc[epsilon]RI: Yamasaki, S.; Saito, T; Role of Oxidants in Mast Cell Activation: Suzuki, Y.; Yoshimaru, T.; Inoue, T.; Niide, O.; Ra, C; Roles of Adaptor Molecules in Mast Cell Activation: Tkaczyk, C.; Iwaki, S.; Metcalfe, D.D.; Gilfillan, A.M; Eicosanoid Mediators of Mast Cells: Receptors, Regulation of Synthesis, and Pathobiologic Implications: Boyce, J.A; Role of Mast Cell Proteases in Tissue Remodeling: Saito, H; Mast Cell Mediators in Airway Remodeling: Oh, C.K; Mast Cell-Derived Cytokine Expression Induced via Fc Receptors and Toll-Like Receptors: Okayama, Y; Mast Cells in Allergic Airway Disease and Chronic Rhinosinusitis: Pawankar, R; Chemokine Receptor Expression by Mast Cells: Juremalm, M.; Nilsson, G; Mast Cell [beta]2-Adrenoceptors: Kay, L.J.; Peachell, P.T; Potential Role of Stem Cell Factor in the Asthma Control by Glucocorticoids: Da Silva, C.A.; Frossard, N; Mast Cell Ion Channels: Bradding, P; Using Mast Cell Knock-In Mice to Analyze the Roles of Mast Cells in Allergic Responses in vivo: Tsai, M; Grimbaldeston, M.A.; Yu, M.; Tam, S.-Y.; Galli, S.J; Mast Cell-Specific Genes - New Drug Targets/Pathogenesis: Saito, H.

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