Overview

Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.

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9783527349913

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Prof. Aihua Zhang is the Laboratory Director of Functional Metabolomics Laboratory, National Chinmedomics Research Center, Sino-America Chinmedomics Technology Collaboration Center, Heilongjiang University of Chinese Medicine, China. He has received numerous scientific awards, including the CHPHARS-SERVIER Young Investigator Awards in Pharmacology, Young and Middle-aged Innovative Talent Award of Chinese Society of Traditional Chinese Medicine, First Prize of Science and Technology Award of Chinese Society of Chinese Medicine, First Prize of Science and Technology Award of China Association of Integrative Medicine, etc. He is also the Deputy Secretary-General of Chinese Medicine Identification Committee of World Federation of Chinese Medicine Societies. Prof. Dr. Wanying Wang is the research personnel of State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau. She mainly engaged in herbal ingredient analysis and effect evaluation.

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