Overview

Section I of this manual derives from the European Workshop for Rheumatology Research consensus finding study on autoantibodies. It includes methods which have been validated by many European laboratories undertaking analysis of sera in workshops (i.e. the methods have been found to be practically useful and to lead to consistent inter-laboratory results). Section II is a full compilation of information on autoantigens and the clinical significance of corresponding autoantibodies. The book should appeal to bench scientists, including immunologists and molecular biologists, as well as clinicians taking care of patients with rheumatic diseases and autoimmune disorders.

Full Product Details

Author:   W.J. van Venrooij ,  Ravinder N. Maini
Publisher:   Springer
Imprint:   Springer
Edition:   1996 ed.
Weight:   0.001kg
ISBN:  

9780792322191

ISBN 10:   0792322193
Pages:   742
Publication Date:   30 June 1993
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Spiral bound
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Section A: Methods of Autoantibody Detection, Introduction The Editors.- 1. International cooperative activities in standardization of antinuclear antibodies.- 2. Detection of antinuclear antibodies by immunofluorescence.- 3. Counterimmunoelectrophoresis and immunodiffusion for the detection of antibodies to soluble cellular antigens.- 4. Protein Blotting.- 5. Enzyme-linked immunosorbant assay in the rheumatological laboratory.- 6. Immunoprecipitation of labelled proteins.- 7. Analysis of autoimmune sera by immunoprecipitation of cellular RNPs.- 8. Measurement of antibodies to DNA.- 9. Methods to detect autoantibodies to neutrophilic granulocyte.- 10. Detection of antiperinuclear factor and antikeratin antibodies.- 11. Standards and reference preparations.- Section B: Autoantigens, Introduction The Editors.- 1. Autoantigens in Rheumatoid Arthritis (RA).- 1. RF (rheumatoïd factor).- 2. APF (antiperinuclear factor).- 3. RA-33 (hnRNP-A2).- 4. Collagen II.- 5. The autoantigens defined by antikeratin antibodies (AKA).- 2. Autoantigens in Systemic Lupus Erythematosus (SLE).- 1. DNA.- 2. Histones.- 3. Ubiquitin.- 4. Sm.- 5. Ribosomal RNP.- 6. Ku.- 7. PCNA.- 8. Phospholipids.- 3. Autoantigens in SLE-overlap syndromes.- 1. The U1 snRNP complex.- 4. Autoantigens in Sjögren’s syndrome.- 1. Ro/SS-A.- 2. La/SS-B.- 5. Autoantigens in Scleroderma.- 1. DNA Topoisomerase 1.- 2. Centromere Proteins.- 3. Fibrillarin.- 4. PM/Scl.- 6. Autoantigens in Myositis.- 1. Transfer RNA synthetases.- 7. Autoantigens in Vasculitis.- 1. Proteinase 3 (c-ANCA).- 2. Myeloperoxidase (MPO).- 8. Autoantigens in other diseases.- 1. Mitochondrial autoantigens.- 2. P80 coilin.- Section C: Clinical Significance of Autoantibodies, Introduction The Editors.- 1. Autoantibodies in Rheumatoid Arthritis.- 1.1Rheumatoïd factor.- 2. Autoantibodies in SLE.- 2.1 Autoantibodies to double-stranded DNA.- 2.2 Autoantibodies to histones, Sm and ubiquitins.- 2.3 Autoantibodies to Ku and related antigens.- 2.4 Autoantibodies to PCNA.- 2.5 Autoantibodies to phospholipids.- 3. Autoantibodies in SLE-overlap syndromes.- 3.1 Autoantibodies to U1snRNP.- 4. Autoantibodies in Sjögren’s syndrome.- Anti-Ro/SSA and anti-La/SSB antibodies.- 5. Autoantibodies in Scleroderma.- 5.1 Anti-centromere antibodies.- 6. Autoantibodies in Myositis.- 6.1 Transfer RNA synthetases.- 7. Autoantibodies in Vasculitis.- 7.1 Anti-neutrophil cytoplasmic antibody.- 8. Autoantibodies in other diseases.- 8.1 Anti-mitochondria] antibody in primary biliary cirrhosis.- 8.2 Autoantibodies to the coiled body and other nuclear bodies.

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