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Author:   Murray F. Brennan ,  Cristina R. Antonescu ,  Kaled M. Alektiar ,  Robert G. Maki
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   2nd ed. 2016
Dimensions:   Width: 15.50cm , Height: 2.40cm , Length: 23.50cm
Weight:   0.966kg
ISBN:  

9783319419046

ISBN 10:   3319419048
Pages:   399
Publication Date:   22 December 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

                                     Management of Soft Tissue Sarcoma     Table of Contents   Preface     Part I Introduction   1.         General Description ·         Introduction ·         Incidence and Prevalence ·         Predisposing and Genetic Factors ·         References   2.         Natural History – Importance of Size, Site, Histopathology ·         Natural History ·         Influence of Site ·         Staging ·         Staging of Retroperitoneal Visceral Sarcoma ·         Prognostic Factors for Extremity and Superficial Soft Tissue Sarcoma ·         Disease-Specific Survival ·         Prognostic Factors for Survival Following Local Recurrence of Extremity Sarcoma ·         Prognostic Factors: Nomograms ·         References   3.         General Statement as to Efficacy Surgery / Chemotherapy / Radiation Therapy ·         Extent of primary surgery ·         Surgical Treatment of Local Recurrence ·         Diagnostic Imaging ·         Surgery for Metastatic Disease o   Pulmonary Metastasis o   Surgery and the Management of Sarcoma Liver Metastasis ·         Radiation Therapy o   Adjuvant Radiation Therapy o   Dose of Radiation Therapy o   Adjuvant Brachytherapy o   Radiation Therapy in the Presence of Positive Microscopic Margins o   Definitive Radiation Therapy o   Radiation to Patients with Neurovascular Involvement o   Wound Complications of Radiation Therapy o   Adjuvant and Neoadjuvant Chemotherapy for Soft Tissue Sarcomas o   Sarcomas More Common in Adults o   Larger Randomized Studies o   Selected Meta-analyses of Randomized Trials of Adjuvant Chemotherapy o   Adjuvant Therapy for GIST o   Sarcomas More Common in Pediatric Setting o   Brief comments regarding chemotherapy for metastatic soft tissue sarcoma o   Newer Systemic Agents ·         Special Techniques for Primary & Locally Recurrent Disease o   Intra-arterial Chemotherapy o   Limb Perfusion and Hyperthermia o   Immunotherapy for Sarcomas <·         References     Part II   Management by Histopathology   4.                  Gastrointestinal stromal tumor ·         Imaging ·         Familial GIST ·         Natural History ·         Diagnosis / Molecular Pathology ·         Treatment o Adjuvant Imatinib for Primary GIST o Neoadjuvant Therapy for Primary Disease not amenable to Surgery< o Treatment of Recurrence o Imatinib: The First Small Molecule Oral Kinase Inhibitor for Metastatic GIST Failing Imatinib & Sunitinib o Systemic Targeted Therapy for Metastatic GIST o Dose Intensity over Time o Imatinib Pharmacokinetics ·         Second-Line Sunitinib for Imatinib-Resistant Metastatic GIST o Other Tyrosine Kinase Inhibitors for Metastatic GIST o Failing Imatinib and Sunitinib o GRID Trial ·         Newer Agents for GIST ·         References   5.                  Liposarcoma ·         Imaging ·         Diagnosis ·         Treatment ·         Radiation Therapy for Liposarcoma ·         Systemic Therapy: General Considerations ·         Adjuvant Therapy ·         Treatment of Metastatic Disease ·         Outcome ·         Outcome Following Metastasis ·         References   6.                  Leiomyosarcoma ·         Imaging ·         Diagnosis, Molecular Pathology ·         Primary Treatment ·         Radiation Therapy ·         Systemic Therapy o   Adjuvant Chemotherapy for Leiomyosarcoma ·         Outcomes after Primary Therapy ·         Patterns of Recurrence ·         Treatment of Recurrence ·         Metastatic Disease ·         References   7.                  Undifferentiated Pleomorphic Sarcoma (UPS) (Malignant Fibrous Histiocytoma:  MFH) Myxofibrosarcoma ·         Imaging ·         Diagnosis, Molecular Pathology ·         Natural History ·         Treatment ·         Radiation Therapy ·         Metastatic Disease ·         Adjuvant Chemotherapy ·         Outcome ·         References   8.                  Synovial Sarcoma ·         Imaging ·         Diagnosis, Molecular Pathology ·         Treatment ·         Radiation Therapy ·         Chemotherapy ·         Treatment of Recurrence o   Local Recurrence o   Systemic Treatment ·         Outcome ·         References                    9.                  Malignant Peripheral Nerve Sheath Tumor (MPNST) / Triton Tumor ·         Presentation ·         Imaging ·         Diagnosis, Pathology ·         Neurofibromatosis Type 1 and Outcome ·         Treatment ·         Radiation Therapy ·         Chemotherapy for MPNST ·         Outcome ·         References     10.              Desmoid Tumor / Deep-Seated Fibromatosis (Desmoid-Type Fibromatosis) ·         Clinical Presentation ·         Imaging ·         Diagnosis, Molecular Pathology ·         Natural History ·         Treatment ·         Treatment of Recurrence <·         Systemic Therapy ·         Treatment by Observation ·         Radiation Therapy ·         Patterns of Failure ·         Outcome ·         References   11.              Solitary Fibrous Tumor / Hemangiopericytoma ·         Doege-Potter Syndrome ·         Primary Therapy ·         Systemic Therapy for Metastatic Disease ·         Outcome ·         References   12.              Fibrosarcoma and its Variants ·         Outcome ·         Dermatofibrosarcoma Protuberans ·         Outcome ·         Low-Grade Fibromyxoid Sarcoma (of Evans Tumor) ·         Outcome ·         Sclerosing Epithelioid Fibrosarcoma ·         Inflammatory Myofibroblastic Tumor ·         Infantile Fibrosarcoma ·         Myxoinflammatory Fibroblastic Sarcoma / Inflammatory Myxohyaline Tumor of Distal Extremities ·         Adult-Type Fibrosarcoma ·         References   13.              Vascular Sarcomas ·         Epithelioid Hemangioendothelioma ·         Angiosarcoma / Lymphangiosarcoma ·         Outcome ·         Kaposi Sarcoma ·         References   14.              Epithelioid Sarcoma ·         Outcome ·         References   15.              Sarcomas More Common in Children Soft Tissue Sarcomas More Commonly Observed in Pediatric Patients Ewing Sarcoma Family of Tumors (EFT) Demographics Primary Therapy Adjuvant Chemotherapy High-Dose Systemic Therapy for Metastatic Disease Standard Cytotoxic Chemotherapy After Disease Relapse Investigational Approaches Ewing Sarcoma-Like Tumors Rhabdomyosarcoma Demographics Molecular Biology Risk Stratification Staging Imaging Primary Therapy Chemotherapy for Metastatic Disease Embryonal Sarcoma References   16.              Radiation-Induced Sarcoma ·         References   17.              Alveolar Soft Part Sarcoma ·         Imaging ·         Diagnosis, Molecular Pathology ·         Primary Treatment ·         Treatment of Metastatic Disease ·         Outcome ·         References   18.              Clear Cell Sarcoma / Melanoma of Soft Parts ·         Imaging ·         Diagnosis, Molecular Pathology ·         Treatment ·         Outcome ·           19.              Desmoplastic Small Round Cell Tumor ·         Imaging ·         Diagnosis ·         Treatment ·         Outcome ·         References   20.              Extraskeletal Myxoid Chondrosarcoma ·         Imaging ·         Diagnosis ·         Treatment ·         Outcome ·         Mesenchymal Chondrosarcoma ·         References   21.              Other Uterine Sarcomas ·         Low Grade Endometrial Stromal Sarcoma o   Diagnosis o   Treatment  o   Outcome ·         High Grade Endometrial Stromal Sarcoma o   Outcome ·         Undifferentiated Uterine Sarcoma (UUS) ·         Uterine Carcinosarcomas and Other Malignant Mixed Müllerian Tumors ·         PEComas o   Outcome ·         References   22.              Extraskeletal Osteogenic Sarcoma ·         Imaging ·         Diagnosis ·         Treatment ·         Outcome ·         References   23.              Sustentacular Tumors of Lymph Tissue ·         Follicular Dendritic Cell Tumor (Dendritic Reticulum Cell Tumor [FDCT]) and Interdigitating Reticulum Cell Tumor (IDRCT) ·         True Histiocytic Sarcoma ·         Langerhans Cell Tumors ·         Outcome ·         References   24.              Uncommon / Unique Sites ·         Heart and Great Vessels ·         Primary Sarcomas of the Breast o   Phylloides Tumor o   Diagnosis o   Outcome ·         Head and Neck o   Treatment ·         Primary Sarcomas of the Mediastinum ·         Liver ·             Part III           Benign and Less Aggressive Lesions   25.              Mostly Benign / Rarely Metastasizing ·         Ossifying Fibromyxoid Tumor ·         Perivascular Epithelial Cell Tumor (PEComa) & Related Entities,  Lymphangioleiomyomatosis, Angiomyolipoma, and Sugar Cell Tumor ·         Therapy ·         Giant Cell Tumor of Tendon Sheath / Pigmented Villonodular Synovitis ·         Myoepithelioma of Soft Tissue ·         Glomus tumor <·         References                           26.              Benign Tumors ·         Lipoma          ·         Lipomatosis   ·         Lipoblastoma / Lipoblastomatosis ·         Angiolipoma ·         Angiomyolipoma ·         Angiomyelolipoma ·         Hibernoma ·         Elastofibroma ·         Granular Cell Tumor ·         Hemangioma ·         Leiomyoma ·         Schwannoma ·         Neurofibroma ·         Myxoma ·         Angiomyxoma ·         Angiofibroma ·         References   27.              Reactive Lesions ·         Myositis Ossificans ·         Nodular Fasciitis                   ·         Sarcoma Masquerade ·         References       Suggested Keywords   Index

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Author Information

Murray F. Brennan, MDInternational Center & Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew York, NY Cristina R. Antonescu, MDDepartment of PathologyMemorial Sloan-Kettering Cancer CenterNew York, NY Kaled M. Alektiar, MDDepartment of Radiation OncologyMemorial Sloan-Kettering Cancer CenterNew York, NY Robert G. Maki, MD, PhDGreat Neck, NY Cold Spring Harbor Laboratory Cold Spring Harbor, NY

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