Overview

Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.

Full Product Details

Author:   Raffaele Badolato ,  Silvano Sozzani
Publisher:   Birkhauser Verlag AG
Imprint:   Birkhauser Verlag AG
Edition:   2006 ed.
Weight:   0.642kg
ISBN:  

9783764373085

ISBN 10:   3764373083
Pages:   253
Publication Date:   18 July 2006
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Lymphocyte trafficking: from immunology paradigms to disease mechanisms.- Lymphocyte trafficking: from immunology paradigms to disease mechanisms.- Physiology of lymphocyte trafficking.- Biology of chemokines.- Lymphocyte-endothelial cell interaction.- Chemokine receptor expression in effector and memory T cell subsets.- Migration of dendritic cell subsets.- Migration of NK cells.- Immunopathology of lymphocyte trafficking.- Lymphocyte trafficking and chemokine receptors during pulmonary disease.- Lymphocyte migration to the brain.- Lymphocyte migration to the kidney.- Leukocyte migration to pancreatic islets: a critical step in the pathogenesis of type 1 diabetes.- Controlling leukocyte trafficking in disease.- Inherited disorders of lymphocyte trafficking.- Leukocyte adhesion deficiency.- Wiskott-Aldrich syndrome as a model of cytoskeleton defects.- From CXCR4 mutations to WHIM syndrome.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions