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OverviewThe third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver’s role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases. Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation. The book begins with an analysis of the core concepts of immunology, including the definition of autoimmunity and its unique application to the liver, a tolerogenic organ. Subsequent chapters then explore the biological elements of liver diseases caused by epigenetics, genetics, and innate and adaptive immunity. Specific clinical presentations and aspects of liver diseases are also examined, such as Hepatitis C, non-alcoholic fatty liver disease and parasitic infections. Closing chapters then discuss liver diseases among specific populations, including pediatrics, those with comorbidities and preexisting conditions, pregnant women, and finally patients with transplanted organs. A timely and invaluable update to the clinical literature, Liver Immunology: Principles and Practice, Third Edition, is once again a comprehensive work that will not only enhance the understanding of liver diseases but also provide the kind of novel insights that greatly accelerates the evidence-based care of children and adults afflicted with these diseases. This volume is again a must-read for clinicians at all levels, for investigators and for students. Full Product DetailsAuthor: M. Eric Gershwin , John M. Vierling , Atsushi Tanaka , Michael P. MannsPublisher: Springer Nature Switzerland AG Imprint: Springer Nature Switzerland AG Edition: 3rd ed. 2020 Weight: 1.844kg ISBN: 9783030517113ISBN 10: 303051711 Pages: 633 Publication Date: 05 November 2021 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsPART 1: Basic Concepts in Liver Immunology 1. Core concepts in immunology, including discussion of innate and adaptive immunity as it relates to liver 2. The liver as a lymphoid organ 3. The definition of autoimmunity and its unique application to the seat of tolerance, the liver 4. The uniqueness of Innate immunity 5. Adaptive immunity and Clinical Definition of Autoantibodies 6. The genetic basis of liver autoimmunity 7. The epigenetic basis of loss of tolerance 8. The gut liver access and the microbiome PART 2: Clinical Aspects of Liver Immunology 9. Bile acids and bilirubin in liver immunology 10. Use of the Clinical Laboratory 11. The pathologist’s approach to reviewing liver histology 12. Bacterial and parasitic diseases of the liver 13. Hepatitis B and Hepatitis D 14. Hepatitis C 15. Other hepatitis virus infections 16. The geoepidemiology of autoimmune liver disease 17. Primary biliary cholangitis 18. Autoimmune hepatitis 19. Primary sclerosing cholangitis 20. Cholestatic variants of autoimmune hepatitis and the concept of overlap 21. IgG4-related diseases 22. Alcoholic liver disease 23. Non-alcoholic fatty liver disease 24. Pediatric liver disease 25. Acute liver failure 26. Immunotherapy and its complications 27. Acute-on-chronic liver failure 28. Drug-induced liver injury 29. Hepatobiliary cancers and immunology 30. Graft-vs-host disease 31. Liver transplantation 32. Immunopathogenesis of liver diseases unique to pregnancyReviewsAuthor InformationM. Eric Gershwin, MD Distinguished Professor of Medicine The Jack and Donald Chia Endowed Professor University of California School of Medicine Davis, CA USA John M. Vierling, MD Professor of Medicine and Surgery Chief of Hepatology Director of Baylor Liver Health Baylor College of Medicine Houston, TX USA Atsushi Tanaka, MD, PhD Professor Department of Medicine Teikyo University School of Medicine Tokyo, Japan Michael P. Manns, MD Professor and Department of Medicine Chair Department of Gastroenterology, Hepatology, and Endocrinology Hannover Medical School Hannover, Germany Tab Content 6Author Website:Countries AvailableAll regions |
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