Overview

This volume brings together information on basic science research and its potential clinical application. The molecular and cell biology of liver growth is thoroughly reviewed, with an emphasis on the interaction of different cell types and the involvement of the extra-cellular matrix. Experimental models of liver repair following injury are summarized and the involvement of growth factor families discussed. Several chapters are devoted to potential clinical applications.

Full Product Details

Author:   A. Strain ,  A.M. Diehl
Publisher:   Chapman and Hall
Imprint:   Chapman and Hall
Dimensions:   Width: 17.80cm , Height: 3.80cm , Length: 25.40cm
Weight:   1.642kg
ISBN:  

9780412712609

ISBN 10:   0412712601
Pages:   662
Publication Date:   31 December 1997
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

One Molecular and Cellular Analysis of Liver Growth.- 1 Liver regeneration following partial hepatectomy: genes and metabolism.- 2 Liver regeneration following hepatic injury.- 3 Epithelial stem-like cells of the rodent liver.- 4 Transgenic animals as models for hepatocarcinogenesis.- 5 Gene knockout animal models.- 6 Biological activity of growth factors in vivo.- Two Growth Factors.- 7 The EGF/TGF? family of growth factors and their receptors.- 8 Hepatocyte growth factor in liver growth and differentiation.- 9 The fibroblast growth factor family.- 10 Growth inhibitory signals and liver regeneration: the TGF? superfamily.- 11 Cytokines.- Three Signaling Events.- 12 Proto-oncogenes/transcription factors.- 13 Cyclins and gap junctions in liver growth and repair.- 14 Intracellular signal transduction in liver regeneration.- Four Biology of the Extracellular Matrix and Non-Parenchymal Cells.- 15 Proteoglycans.- 16 Regulation of collagen gene expression.- 17 The extracellular matrix in liver regeneration.- 18 Hepatocyte co-culture, three-dimensional culture models and the extracellular matrix.- 19 Kupffer cells and endothelial cells.- 20 Hepatic stellate cells.- Five Human Liver Growth and Clinical Applications.- 21 Human liver growth and development.- 22 Human liver growth in fibrosis and cirrhosis.- 23 Hepatocyte transplantation: novel applications.- 24 Hepatic gene therapy.- 25 Artificial liver support.

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