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Author:   Mulchand S. Patel ,  Lester Packer
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Weight:   0.453kg
ISBN:  

9780367387655

ISBN 10:   0367387654
Pages:   556
Publication Date:   19 September 2019
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Discovery molecular structure,A Trail of Research on Lipoic Acid, Lipoic Acid Biosynthesis, The Search for Potent α-lipoic Acid Derivatives: Chemical and Pharmacological Aspects, Novel Indole Lipoic Acid Derivatives: Synthesis and their Antioxidant Effects, Metabolic aspects, The α-keto Acid Dehydrogenase Complexes and Glycine Cleavage System: Their Involvement in Pathways of Carbohydrate, Protein, and Fat Metabolism, Pyruvate Dehydrogenase Complex Regulation and Lipoic Acid, Role of Lipoyl Domains in the Function and Regulation of the Mammalian Pyruvate Dehydrogenase Complex, Inactivation and Inhibition of α-ketoglutarate Dehydrogenase: Oxidative Modulation of Lipoic Acid, Lipoate-Protein Ligase A: Structure and Function, A Review of the Stability & Preliminary Evaluation of the Plasma Pharmacokinetics of R-lipoic acid & R-Dihydrolipoic Acid Dosage Forms in Human Plasma from Healthy Volunteers, The Pharmacokinetics, Metabolism and Renal Excretion of α-lipoic Acid and its Main Metabolites in Humans, Modulation of Cellular Redox and Metabolic Status by Lipoic Acid, The “Redoxin” Connection of Lipoic Acid, Lipoic Acid as an Inducer of Phase II Detoxification Enzymes through Activation of Nrf2-dependent Gene Expression, Clinical aspects, Deficiency Disorders of Components of the PDH Complex: E2, BP & E3 Deficiencies, The Relationship between Primary Biliary Cirrhosis and Lipoic Acid, Effects of Lipoic Acid on Insulin Action in Animal Models of Insulin Resistance, Activation of Cytoprotective Signaling Pathways by Alpha-Lipoic Acid, Selenotrisulfide Derivatives of Alpha Lipoic Acid: Potential Use as a Novel Topical Antioxidant, Alpha-Lipoic Acid: A Potent Mitochondrial Nutrient for Improving Memory Deficit, Oxidative Stress, and Mitochondrial Dysfunction, Effects of Alpha-Lipoic Acid on AMP-Activated Kinase in Different Tissues: Therapeutic Implications for the Metabolic Syndrome

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Mulchand S. Patel, Lester Packer

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