Overview

This book has three aims. The first is to describe to scientists interested in basic biogerontology a panel of available model organisms where the aging process has been well-studied and where (with the exclusion of man) external interventions have been proven capable of extending life span. The second aim of the book is to emphasize the commonalities among experimental manipulations that are able to confer life extension across species. The third aim of the book is to offer objective and reasonable speculations in the science of life span extension to scientists of diverse background and to physicians. The scope of the book will be broad. Model systems ranging form unicellular organisms to man will be examined. However, the overall context of the discussion will be the common mechanisms relating aging and longevity that have been identified in each system These common mechanisms will provide the unifying feature for the discussion and will provide the reader with an understanding of the possible links between aging and longevity that have been uncovered in the past decade.

Full Product Details

Author:   Christian Sell ,  Antonello Lorenzini ,  Holly M. Brown-Borg
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2009 ed.
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   0.534kg
ISBN:  

9781603275064

ISBN 10:   1603275061
Pages:   198
Publication Date:   25 August 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Yeast.- Reprogramming Cell Survival and Longevity: The Role of Tor, Sch9, Ras, and Sir2.- Caenorhabditis elegans.- 2 Common Aging Mechanisms: Energy Metabolism and Longevity in Caenorhabditis elegans.- 3 Conserved Mechanisms of Life-Span Regulation and Extension in Caenorhabditis elegans.- Drosophila melanogaster.- The Genetic Architecture of Longevity.- Mild Stress and Life Extension in Drosophila melanogaster.- Rodents.- Global Food Restriction.- Growth Hormone and Aging in Mice.- Comparative Biology of Aging.- Exploiting Natural Variation in Life Span to Evaluate Mechanisms of Aging.- Slow Aging: Insights from an Exceptionally Long-Lived Rodent, the Naked Mole-Rat.- Life Extension in the Short-Lived Fish Nothobranchius furzeri.- Aging in Humans.- Aging and Longevity in Animal Models and Humans.

Reviews

From the reviews: This multiauthored book reviews the mechanisms of life-span extension across the animal kingdom, including man. ! The audience here is researchers into the nature of aging and longevity. Many scientists looking at redox reactions in the body find themselves ultimately researching the nature of aging. For them, this is a useful guide. ! This compact, well-edited book is a timely review of a complex subject. (David O. Staats, Doody's Review Service, April, 2010)

From the reviews: This multiauthored book reviews the mechanisms of life-span extension across the animal kingdom, including man. ... The audience here is researchers into the nature of aging and longevity. Many scientists looking at redox reactions in the body find themselves ultimately researching the nature of aging. For them, this is a useful guide. ... This compact, well-edited book is a timely review of a complex subject. (David O. Staats, Doody's Review Service, April, 2010)

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