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Author:   Alexander M. Vaiserman ,  Alexey A. Moskalev ,  Elena G. Pasyukova
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2015
Volume:   3
Weight:   6.166kg
ISBN:  

9783319382104

ISBN 10:   3319382101
Pages:   353
Publication Date:   17 October 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

 Preface.- SECTION I: Genetic regulation of longevity.- Mutations and quantitative genetic variation: lessons from Drosophila.- Modulation of Drosophila lifespan by neuronal genes.- Life span, stress resistance and age-dependent transcriptome dynamics in fruit flies with constitutive and conditional overexpression of GADD45.- Superoxide dismutase over-expression and the mitochondrial unfolded protein response.- Effect of Wolbachia infection on aging and longevity-associated genes in Drosophila.- SECTION II: Drosophila models for aging-associated diseases.- Skeletal muscle homeostasis and aging.- Drosophila models of cardiac disease.- Genetic modulation of cardiac functional aging.- Functional links between circadian clocks, redox state and aging in Drosophila.- Drosophila models in therapeutic drug discovery.- SECTION III: Life-extending treatments.- Phytochemicals with lifespan extension effect in Drosophila.- Life extension in Drosophila by inhibitors of histone deacetylases.- Drosophila healthspan extension using dietary manipulation.- The effect of the artificial atmosphere on the flies’ longevity.- Effects of several mild stresses applied in adults on aging and longevity.- Life extension via stage-specific drug interventions in Drosophila.- Index.

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