Overview

The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. This volume outlines some of the cellular and molecular mechanisms of inflammation with contributions from researchers. It provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This should will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.

Full Product Details

Author:   Tucker Collins
Publisher:   Springer
Imprint:   Springer
Edition:   2001 ed.
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   1.470kg
ISBN:  

9780792372233

ISBN 10:   0792372239
Pages:   327
Publication Date:   30 November 2000
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Preface: Transcriptional Control of Cell Adhesion Molecules; T. Collins, M. Gerritsen. 1. The Selectins in Leukocyte Recruitment; R. McEver. 2. Transcriptional Regulation of the E-Selectin Gene; T. Collins, K.-A. Sheppard, S. Simeonidis, D. Rose. 3. The Immunoglobulin Superfamily in Leukocyte Recruitment; U. von Andrian. 4. Regulation of Intercellular Adhesion Molecule-1 Gene Expression; T. Parks, M. Gerritsen. 5. Transcriptional Regulation of VCAM-1; A. Neish, S. Aggarwal, T. Collins. 6. Activation of Nuclear Factor-kappaB; F. Lee, R. Peters, J. Chen, T. Maniatis. 7. The Basal Transcriptional Apparatus; S. Anderson, J. Parvin. 8. Therapeutic Regulation of Leukocyte Adhesion Molecule Expression; M. Gerritsen. 9. The NF-kappaB System and Drug Discovery; A. Manning. Index.

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