Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control: Insights for Drug Discovery
Author:   Tucker Collins
Publisher:   Springer
Edition:   2001 ed.
ISBN:  

9780792372233


Pages:   327
Publication Date:   30 November 2000
Format:   Hardback
Availability:   In Print   Availability explained
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Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control: Insights for Drug Discovery


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Overview

The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. This volume outlines some of the cellular and molecular mechanisms of inflammation with contributions from researchers. It provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This should will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.

Full Product Details

Author:   Tucker Collins
Publisher:   Springer
Imprint:   Springer
Edition:   2001 ed.
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   1.470kg
ISBN:  

9780792372233


ISBN 10:   0792372239
Pages:   327
Publication Date:   30 November 2000
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

1. The Selectins in Leukocyte Recruitment.- 2. Transcriptional Regulation of the E-Selectin Gene.- 3. The Immunoglobulin Superfamily in Leukocyte Recruitment.- 4. Regulation of Intercellular Adhesion Molecule (ICAM) Gene Expression.- 5. Transcriptional Regulation of VCAM-1.- 6. Activation of Nuclear Factor-KB.- 7. The Basal Transcriptional Apparatus.- 8. Therapeutic Regulation of Leukocyte Adhesion Molecule Expression.- 9. The NF-kB System and Drug Discovery.

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