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Author:   Sam Dagogo-Jack, MD
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2015
Dimensions:   Width: 17.80cm , Height: 1.70cm , Length: 25.40cm
Weight:   5.888kg
ISBN:  

9783319354132

ISBN 10:   3319354132
Pages:   287
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Discovery of leptin and elucidation of leptin gene expression.- Leptin receptors and mechanism of action.- Leptin interaction with brain orexigenic and anorexigenic pathways.- Measurement of circulating leptin and soluble leptin receptors.- Physiological and hormonal factors that influence leptin production.- Leptin, obesity and leptin resistance.- Leptin and intermediary metabolism: Focus on glucoregulation and lipid metabolism.- Leptin in acute stress.- Leptin and the kidney.- Leptin, immune function, and inflammation.- Leptin and bone.- Leptin, cell cycle, and cancer.- Leptin, the autonomic nervous system, and hypertension.- Dynamic leptin secretion in obesity and diabetes.- Leptin therapy of congenital leptin deficiency.- Leptin therapy in people with normal leptin gene.- Leptin therapy in patients with lipodystrophy and syndromic insulin resistance.- Leptin therapy in women with hypothalamic amenorrhea.- Leptin therapy as a substitute for insulin replacement in experimental models of diabetes: Clinical implications in humans.- Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases.

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Author Information

Sam Dagogo-Jack, MD, FRCP, A.C. Mullins Chair in Translational Research, Professor of Medicine and Director, Division of Endocrinology, Diabetes and Metabolism, Director, General Clinical Research Center, The University of Tennessee Health Science Center, Memphis, TN, USA

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