Lentiviral Vector Systems for Gene Transfer
Author:   Gary L. Buchschacher Jr.
Publisher:   Springer Science+Business Media
Edition:   2003 ed.
ISBN:  

9780306477027


Pages:   195
Publication Date:   31 January 2003
Format:   Hardback
Availability:   In Print   Availability explained
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Lentiviral Vector Systems for Gene Transfer


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Overview

The human immunodeficiency viruses (HIVs), in particular HIV-1, are the causative agent responsible for the current worldwide epidemic of acquired immunodeficiency syndrome (AIDS). A major effort has thus been underway over the past two decades to understand and control this pathogen. During this time, an enormous knowledge base has accumulated regarding the role of viral factors in the HIV-1 life cycle, and the interaction of HIV-1 with the host cell is becoming increasingly understood. Certain features of HIV, for example its ability to infect non-dividing cells, are being exploited in the development of novel gene therapy vehicles. This volume provides an overview of the current information regarding the HIV replication cycle and will serve as an introduction to subsequent chapters that address specific aspects of lentiviral-based gene therapy.

Full Product Details

Author:   Gary L. Buchschacher Jr.
Publisher:   Springer Science+Business Media
Imprint:   Kluwer Academic/Plenum Publishers
Edition:   2003 ed.
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   1.040kg
ISBN:  

9780306477027


ISBN 10:   0306477025
Pages:   195
Publication Date:   31 January 2003
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

From the contents: Preface.- 1: Introduction to Retroviruses and Retroviral Vectors.- 2: HIV-1 Replication.- 3: Determinants for Lentiviral Infection of Non-Dividing Cells.- 4: HIV-1 Vector Systems.- 5: HIV-2 and SIV Vector Systems.- 6: Vector Systems.- 7: EIAV, CIAV and Other Lentevirus Vector Systems.- 8: Safety Considerations in Vector Development.- 9: Prospects for Gene Therapy Using HIV-Based Vectors.- 10: Ethical Considerations in the Use of Lenteviral Vectors for Genetic Transfer.- Index.

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