Overview

This book is the first to summarize the current knowledge of the cell biology of lens epithelial cells in relation to and in the development of posterior capsular opacification (PCO). PCO remains the most common long-term complication of modern cataract surgery, occurring months or years after cataract surgery, unlike most other complications that tend to arise during or soon after the procedure. Opacification of the posterior capsule appears to be linked to lens epithelial cells that are left behind in the eye during cataract removal. These cells proliferate, migrate across the posterior lens capsule, and undergo changes that result in fibrous or pearl-type opacities in the capsule. The first section of the text explains the molecular mechanism and biology of lens epithelial cells that lead to the incidence of PCO. In the second part, in addition to a description of the mechanism and pathological condition of PCO, surgical methods and devices for preventing PCO are discussed in detail. Lens Epithelium and Capsular Opacification will benefit not only young clinical residents and junior researchers, but also established faculty in the clinical or basic academic field.

Full Product Details

Author:   Shizuya Saika ,  Liliana Werner ,  Frank J. Lovicu
Publisher:   Springer Verlag, Japan
Imprint:   Springer Verlag, Japan
Edition:   2014 ed.
Dimensions:   Width: 15.50cm , Height: 2.50cm , Length: 23.50cm
Weight:   8.668kg
ISBN:  

9784431542995

ISBN 10:   443154299
Pages:   424
Publication Date:   26 August 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

PART I: Lens Epithelial Cell Biology.- Chapter 1. From Zygote to Lens: Emergence of the Lens Epithelium.- Chapter 2. Cell Biology of Lens Epithelial Cells.- Chapter 3. The Lens Capsule – Synthesis, Remodeling and MMPs.- Chapter 4. Lens Epithelial Cell Proliferation.- Chapter 5. Growth Factor Signaling in Lens Fiber Differentiation.- Chapter 6. Lens-Specific Transcription Factors and Their Roles in Diagnosis and Treatment of Human Congenital Cataract.- Chapter 7. Lens Regeneration.- Chapter 8. Fibrotic Modifications of the Lens Epithelium.- Chapter 9. Wound Healing and Epithelial-Mesenchymal Transition in the Lens Epithelium: Roles of Growth Factors and Extracellular Matrix.- Part II: Clinical Science -Pathology.- Chapter 10. Histology of Posterior Capsular Opacification.- Chapter 11. PCO Rates in a Large Series of Human Eyes Obtained Post-Mortem.- Part III: Clinical Outcomes.- Chapter 12. Natural Course of Elschnig Pearl Formation and Disappearance.- Chapter 13. Effect of Posterior Capsule Opacification and Anterior Capsule Contraction on Visual Function.- PART IV: Surgical Methods for PCO Prevention.- Chapter 14. Size of Continuous Curvilinear Capsulorhexis for Prevention of PCO.- Chapter 15. Effect of Anterior Capsule Polishing on Capsule Opacification and YAG Laser Capsulotomy.- Chapter 16. Laser Photolysis System and PCO Prevention.- PART V: Intraocular Lenses/Devices and PCO.- Chapter 17. PCO Prevention: IOL Material Versus IOL Design.- Chapter 18. Capsular and Uveal Biocompatibility of Different IOLs in Eyes with and Without Associated Conditions.- Chapter 19. Capsule-Bending Ring for the Prevention of Posterior Capsule Opacification.- Chapter 20. PCO Prevention with Endocapsular Equator Rings.- Chapter 21. PCO Prevention with IOLs Maintaining an Open or Expanded Capsular Bag.- Chapter 22. Prevention of PCO with the Bag-in-the-lens (BIL).- Chapter 23. Posterior capsule Opacification with Micro incision (MICS) IOLs.- PART VI: Special Cases.- Chapter24. PCO and the Pediatric Eye.

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Author Information

Shizuya Saika, MD, PhD. Professor and Chairman, Department of Ophthalmology Wakayama Medical University School of Medicine 811-1 Kimiidera, Wakayama, 641-0012, Japan TEL: 81-73-447-2300 (5412) FAX: 81-73-448-1991 shizuya@wakayama-med.ac.jp Liliana Werner, MD, PhD Associate Professor Co-Director, Intermountain Ocular Research Center John A. Moran Eye Center University of Utah 65 Mario Capecchi Drive, Salt Lake City, UT 84132 USA TEL: +1 801 581 6586 FAX: +1 801 581 3357 E-mail: liliana.werner@hsc.utah.edu http://uuhsc.utah.edu/MoranEyeCenter/research/faculty/primary/mamalis_werner_lab.htm Frank J. Lovicu, PhD Associate Professor, Lens Research Laboratory Anatomy & Histology, School of Medical Sciences Bosch Institute & Save Sight Institute The University of Sydney Rm S252, Anderson Stuart Building, F13 NSW 2006, Australia TEL: +61 2 9351 5170 FAX: +61 2 9351 2588 E-mail: frank.lovicu@sydney.edu.au

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