Overview
Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases. In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include: Proteomics Glycoprotein Mapping Natural Products Dereplication Lead Identification Screening Open-Access LC/MS In Vitro Drug Screening Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.
Full Product Details
Author: Mike S. Lee ,
Dominic M. Desiderio (University of Tennessee Health Science Center) ,
Nico M. Nibbering (Vrije Universiteit in Amsterdam)
Publisher: John Wiley & Sons Inc
Imprint: Wiley-Interscience
Dimensions:
Width: 16.30cm
, Height: 1.80cm
, Length: 24.10cm
Weight: 0.484kg
ISBN: 9780471405207
ISBN 10: 0471405205
Pages: 256
Publication Date: 14 March 2002
Audience:
College/higher education
,
Professional and scholarly
,
Undergraduate
,
Postgraduate, Research & Scholarly
Format: Hardback
Publisher's Status: Active
Availability: Out of stock
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.
Reviews
!a comprehensive primer and will appeal to laboratory scientists and instructors in the pharmaceutical field! (Analytical Chemistry, November 2002) ...describes...applications in each phase of drug development...provides perspective on changes in strategies for pharmaceutical analysis... (SciTech Book News, Vol. 26, No. 2, June 2002)
...a comprehensive primer and will appeal to laboratory scientists and instructors in the pharmaceutical field... (Analytical Chemistry, November 2002) ...describes...applications in each phase of drug development...provides perspective on changes in strategies for pharmaceutical analysis... (SciTech Book News, Vol. 26, No. 2, June 2002)
Author Information
MIKE S. LEE, PhD, is President of Milestone Development Services, a consulting firm specializing in pharmaceutical analysis and drug development strategies. He lives in Newtown, Pennsylvania.
