Overview

Experimental and clinical investigators join forces to explain our current understanding of lactoferrin. Drawing on many disciplines, the front-line authorities writing here define the known structural features of lactoferrin and describe in detail several of its physiological functions. These include the role of lactoferrin in killing bacteria, and its involvement in cell growth and proliferation, in the modulation of immune function, and in iron absorption. Particular attention is given to lactoferrin functions in the regulation of normal and diseased states. New knowledge of the molecular biology of lactoferrin is also included, along with discussions of commercially viable large-scale production techniques and important new industrial applications. This comprehensive, multidisciplinary work should open the door to the greatly expanded use of lactoferrin as a bioactive reagent in foods and pharmaceuticals. Lactoferrin: Interactions and Biological Functions offers a comprehensive, multidisciplinary view of our present knowledge of lactoferrin. The book should open the way to the expanded use of lactoferrin as a bioactive reagent in foods and pharmaceuticals.

Full Product Details

Author:   T. William Hutchens ,  Bo Lönnerdal
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Volume:   28
Dimensions:   Width: 15.20cm , Height: 2.30cm , Length: 22.90cm
Weight:   0.774kg
ISBN:  

9780896033665

ISBN 10:   089603366
Pages:   408
Publication Date:   24 March 1997
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I: Lactoferrin Structure and Function.- 1. Lactoferrin Structure-Function Relationships: An Overview.- 2. Altered Domain Closure and Iron Binding in Lactoferrin Mutants.- 3. Affinity Mass Spectrometry: Probes with Surfaces Enhanced for Affinity Capture (SEAC) of Lactoferrin.- II: Lactoferrin Gene Expression.- 4. Variants and Biotechnological Use of the Bovine Lactoferrin-Encoding Gene.- 5. Posttranscriptional Regulation of Bovine and Human Lactoferrin: Species Differences and Influence of mRNA Regions.- 6. Mutagenesis of Human Lactoferrin and Expression in Baby Hamster Kidney Cells.- 7. Structural Determination of Two N-Linked Glycans Isolated from Recombinant Human Lactoferrin Expressed in BHK Cells.- 8. Distribution of the Iron-Binding Protein Lactof errin in the Pathological Lesions of Neurodegenerative Diseases.- 9. Lactoferrin Almost Absent from Lactating Rat Mammary Gland Is Replaced by Transferrin.- 10. Estrogen Regulation of Human Lactoferrin Gene Activity: Transcriptional Synergism Between Estrogen Receptorand Related Orphan Receptor.- 11. Expression and Functional Analysis of Recombinant Human Lactoferrin.- 12. Structural and Functional Flexibility of Lactoferrin.- 13. Difference in Binding and Fate of Lactotransferrin in Jurkat Human Lymphoblastic T-Cells and in T-47D Human Breast Cancer Cells.- 14. The Impact of Phagocyte-Lactoferrin Interactions on Inflammation.- 15. Regulation of Lymphocyte Proliferation by Lactoferrin.- 16. Recombinant Human Lactoferrin and Its Variants: Receptor Binding in Human Intestinal Brush-Border Membranes.- III: Functions Related to Lactoferrin Interactions with Prokaryotic and Eukaryotic Cells.- 17. Influence of Lactoferrin on Host—Microbe Interactions.- 18. Bacterial Lactoferrin Receptors in the Neisseriaceae.- 19.Bacteriostatic Effects of Orally Administered Bovine Lactoferrin on Intestinal Bacteria in the Gut of Mice Fed Bovine Milk.- 20. Functional Significance of the Binding of Lactoferrin to DNA.- 21. Specific Binding of Ferrilactoferrin and Ferritransf errin in the Protozoan Leishmania chagasi.- IV: Lactoferrin Metabolism.- 22. Observations on the Metabolism and Cellular Interactions of Lactoferrin.- 23. Lactoferrin as a Possible Transcriptional Regulator: Downmodulation of the Granulocyte-Macrophage Colony-Stimulating Factor Promoter.- V: The Use of Lactoferrin as a Food Additive.- 24. Modification of Infant Formula: The Case of Lactoferrin.- 25. Lactoferrin in Infant Formulas: How and Why?.

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