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Author:   Frank Kozielski, FSB
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of the original 1st ed. 2015
Weight:   4.853kg
ISBN:  

9789402403657

ISBN 10:   9402403655
Pages:   271
Publication Date:   09 October 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Preface.- The kinesin superfamily.- The discovery and development of Eg5 inhibitors for the clinic.- Mechanism of action of Eg5 inhibitors.- Clinical trials of mitotic kinesin inhibitors.- Kif15; a useful target for anti-cancer therapy?.- Down-regulating CENP-E activity: for better or for worse.- The human kinesin-14 motor KifC1/HSET is an attractive anti-cancer drug target.-Kinesin-13 Microtubule Depolymerizing Proteins as targets for cancer therapy.- Chromokinesins in genome maintenance and cancer.- Kif14: a clinically relevant kinesin and potential target for cancer therapy.- Kinesin-8 members and their potential as biomarker or therapeutic target.- The kinesin-6 members MKLP1, MKLP2 and MPP.- Non-motor spindle proteins as cancer chemotherapy targets.- Inhibitors of mitotic kinesins for cancer treatment: consequences for neurons.- Index.

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