Overview
Kernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment. In the absence of treatment kernicterus can produce devastating sequelae and death. The present volume will examine the biochemistry and physiology of bilirubin as well as its hepatic metabolism and renal excretion. Chapters will elaborate bodily disposition of bilirubin and its neuropathology. Both early treatments and current therapy will be discussed in detail. Phototherapy will be presented, and its efficacy and influence on incidence thoroughly examined.
Full Product Details
Author: David W. McCandless
Publisher: Humana Press Inc.
Imprint: Humana Press Inc.
Edition: 2011 ed.
Dimensions:
Width: 15.50cm
, Height: 2.00cm
, Length: 23.50cm
Weight: 0.462kg
ISBN: 9781617797019
ISBN 10: 1617797014
Pages: 286
Publication Date: 24 March 2014
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Paperback
Publisher's Status: Active
Availability: Manufactured on demand
We will order this item for you from a manufactured on demand supplier.
Reviews
From the reviews: “Hyperbilirubinemia and the prevention of development of neurological pathology and/ or death due to kernicterus in newborns is a significant concern for physicians and allied healthcare workers worldwide. … Kernicterus is a worthy addition to the clinical neuroscience literature as a treatise on a condition that preferentially attacks critical brain regions. … it should be read widely by clinicians and public health officers confronted by issues related to the early diagnosis, treatment and rehabilitation of individuals suffering from kernicterus.” (Medical Science Books, May, 2011)
From the reviews: Hyperbilirubinemia and the prevention of development of neurological pathology and/ or death due to kernicterus in newborns is a significant concern for physicians and allied healthcare workers worldwide. ... Kernicterus is a worthy addition to the clinical neuroscience literature as a treatise on a condition that preferentially attacks critical brain regions. ... it should be read widely by clinicians and public health officers confronted by issues related to the early diagnosis, treatment and rehabilitation of individuals suffering from kernicterus. (Medical Science Books, May, 2011)
Author Information
Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 26th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine.Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others
