Overview

Substantial advances in the realm of isoquinoline alkaloids have occurred since The Isoquinoline Alkaloids, Chemistry and Pharmacology, was published in 1972. The present volume represents an effort to describe important developments since that time. The organization of the present book is essentially the same as in The Isoquinoline Alkaloids. Each chapter begins with a discussion of structural elucidation and synthesis, a description of typical reactions then follows, and the chapter ends with coverage of biogenesis, pharmacology, and spectroscopy. New chapters have had to be added to describe the completely new alkaloidal types discovered since 1972. These include baluchistanamine (an isoquinolone- benzylisoquinoline dimer), the aporphine-pavine dimers, the 4,5-dioxoapor- phines, the secoberbines, the 3-arylisoquinolines, eupolauridine, and very recently imerubrine. Another new chapter discusses the chemistry of the aristolo- chic acids and aristolactams, a group of substituted phenanthrenes, obviously of isoquinoline derivation in spite of the fact that they do not incorporate a basic nitrogen function. The aristolochic acids and aristolactams were not in- cluded in The Isoquinoline Alkaloids even though they were known at the time that book was written. On the other hand, one group of alkaloids which was included in The Isoquinoline Alkaloids and nevertheless was deemed not to belong properly in the present work is the naphthalenoisoquinolines, which include ancistro- cladine and its relatives. These bases do not originate biogenetically* from tyrosine, and beside incorporating tetrahydroisoquinoline moieties show no clear structural relationship to the more orthodox isoquinoline alkaloids.

Full Product Details

Author:   Maurice Shamma
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1978
Dimensions:   Width: 15.20cm , Height: 2.20cm , Length: 22.90cm
Weight:   0.646kg
ISBN:  

9781461588214

ISBN 10:   1461588219
Pages:   426
Publication Date:   12 December 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. The Simple Isoquinolines.- 2. The Benzylisoquinolines.- 3. The Isoquinolones.- 4. The Pavines and Isopavines.- 5. The Bisbenzylisoquinolines.- 6. Baluchistanamine: An Isoquinolone-Benzylisoquinoline Dimer.- 7. The Cularines.- 8. The Dibenzopyrrocolines.- 9. The Proaporphines.- 10. The Aporphines.- 11. Pakistanamine: A Proaporphine-Benzylisoquinoline Dimer.- 12. The Aporphine-Benzylisoquinoline Dimers.- 13. The Aporphine-Pavine Dimers.- 14. The Oxoaporphines.- 15. The Phenanthrenes.- 16. The 4,5-Dioxoaporphines.- 17. The Aristolochic Acids and Aristolactams.- 18. The Dibenzazonines.- 19. The Protoberberines and Retroprotoberberines.- 20. The Secoberbines.- 21. The Benzophenanthridines.- 22. The 3-Arylisoquinolines.- 23. The Protopines.- 24. The Phthalideisoquinolines.- 25. The Spirobenzylisoquinolines.- 26. The Rhoeadines.- 27. Emetine and Related Bases.- 28. The Phenethylisoquinolines.- 29. The Homoaporphines and Homoproaporphines.- 30. The 1-Phenylisoquinolines.- 31. The N-Benzyltetrahydroisoquinolines.- 32. Cherylline, a 4-Arylisoquinoline.- 33. The Azafluoranthenes and Tropoloisoquinolines.- 34. Eupolauridine: A 1,6-Diazafluoranthene.- Author Index.

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