Overview

This volume informs about different techniques of isolated liver perfusion already used in clinical practice. Indications for liver perfusion are discussed from a pathological, oncological and surgical point of view. Special aspects of anaesthesia and postoperative management in the intensive care unit are explained. The pathophysiology of hyperthermia, chemotherapeutics and tumour necrosis factor in isolated liver perfusion are described. Clinincal results including the use of tumour necrosis factor in combination with melphalan are reported and the radiological methods of postoperative monitoring of tumour necrosis after therapy are presented.

Full Product Details

Author:   K. J. Oldhafer ,  Hauke Lang ,  Rudolf Pichlmayr
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   147
Weight:   0.440kg
ISBN:  

9783540633365

ISBN 10:   3540633367
Pages:   191
Publication Date:   20 May 1998
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Indication.- Are There Indications for Intraarterial Hepatic Chemotherapy or Isolated Liver Perfusion? The Case of Liver Metastases from Colorectal Cancer. Indications for Isolated Hyperthermic Liver Perfusion: A Surgeon's View. Techniques/Anaesthesia.- Asanguineous Isolated Hyperthermic Perfusion of the Liver: Results of an Experimental Study in Pigs. Hyperthermo-Chemo-Hypoxic Isolated Liver Perfusion for Hepatic Metastases: A Possible Adjuvant Approach. The Surgical Technique of Isolated Hyperthermic Arterial Liver Perfusion in Humans. Monitoring Leakage During Isolated Hepatic Perfusion. Anesthesiological Management During Isolated Liver Perfusion. High-Dose Chemoperfusion.- Percutaneous Isolated Liver Chemoperfusion for Treatment of Unresectable Malignant Liver Tumors: Technique, Pharmacokinetics, Clinical Results. Phase I/II Studies of Isolated Hepatic Perfusion with Mitomycin C or Melphalan in Patients with Colorectal Cancer. Tumor Necrosis Factor.- Molecular Mechanisms of TNF Receptor-Mediated Signaling. Isolated Hepatic Perfusion with Tumor Necrosis Factor Alpha and Melphalan: Experimental Studies in Pigs and Phase I Data from Humans. Isolated Hepatic Perfusion with Extracorporeal Oxygenation Using Hyperthermia, TNF Alpha and Melphalan: Swedish Experience. Radiological Control of Tumor Response.- Role of Ultrasonography for Monitoring Tumor Necrosis After Chemotherapy. CT and MR to Assess the Response of Liver Tumors to Hepatic Perfusion. Future Aspects.- Implications of Shock Proteins Druing Liver Surgery and Liver Perfusion. Towards Gene Therapy for Colorectal Liver Metastases. Subject Index.-

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