Overview

This volume is designed to impart the fundamental concepts in experimental pharmacology, research methodology and biostatistics. Through this book, the readers will learn about different methods involved in drug discovery, experimental animals and their care, equipments and the various bioassays used in experimental pharmacology. This book contains special sections on various drug screening methods involved in the evaluation of different body systems. Certain sections provide the healthcare professionals with the knowledge necessary to interpret clinical research articles, design clinical studies, and learn essential concepts in biostatistics in an expedient and concise manner. Basic principles and applications of simple analytical methods employed in drug analysis are well written under one section.  It focuses on the basic and advanced laboratory techniques and also on computer simulated data, written extensively under the Biostatistics section. The methods used for drug analysis have been described in adequate detail with cross-references for further studies and comprehension. Overall, the book is designed systematically with four broad sections with extensive subdivisions for easy tracking, interpretation, and understanding.

Full Product Details

Author:   Mageshwaran Lakshmanan ,  Deepak Gopal Shewade ,  Gerard Marshall Raj
Publisher:   Springer Verlag, Singapore
Imprint:   Springer Verlag, Singapore
Edition:   1st ed. 2022
Weight:   1.419kg
ISBN:  

9789811953453

ISBN 10:   9811953457
Pages:   910
Publication Date:   17 November 2023
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1. Experimental methodologies involved in the discovery of drugs.- 2. Laboratory animals.- 3. Care and Handling of Laboratory Animals.- 4. Biological Sample Collection from Experimental Animals.- 5. Anaesthesia and Euthanasia of Experimental Animals.- 6. Equipment in experimental Pharmacology.- 7. Bioassay and experiments on isolated muscle preparations.- 8. Experiments on Anaesthetized Intact Animals.- 9. Bioassay of standard compounds.- 10. PRINCIPLES OF EC50, ED50, pD2 and pA2 VALUES OF DRUGS.- 11. Physiological salt solutions.- 12. Validation of animal model.- 13. Screening Methods for the Evaluation of Antidepressant Drugs.- 14. Screening methods for evaluation of antiepileptics.- 15. Screening Methods Involved in the Evaluation of General Anaesthetics.- 16. Screening methods for evaluation of anti-psychotics.- 17. Screening methods for evaluation of sedative and hypnotics.- 18. Screening Methods for the Evaluation of Anxiolytic Drugs.- 19. Screening methods for evaluation of drugs with Anti-Parkinsonism activities.- 20. Screening methods for evaluation of drugs for learning and memory.- 21. Screening Methods Involved in the Evaluation of Antianginal Agents.- 22. Screening methods involved in the evaluation of Anti-hypertensive agents.- 23. Screening methods involved in the evaluation of anti arrhythmic agents.- 24. Screening methods involved in evaluation of cardiotonic drugs (Cardiac Hypertrophy and Insufficiency/ Drugs for Heart Failure).- 25. Screening Methods for the Evaluation of Antiplatelet Drugs.- 26. Screening methods involved in the evaluation of diuretics.- 27. Screening Methods for anti-hyperlipidemic agents.- 28. Screening Methods Involved in the Evaluation of Antiulcer Drugs.- 29. Screening Methods Involved in the Evaluation of Antidiarrheal Drugs (Drugs Affecting Intestinal Motility and Secretion).- 30. Screening Methods Involved in the Evaluation of Antiemetics.- 31. Screening Methods for the Evaluation of Hepatoprotective Agents.- 32. Screening Methods for the Evaluation of Anti-obesity Drugs.- 33. Absorption studies.- 34. Screening methods for evaluation of anti-asthma agents.- 35. Screening Methods for Evaluation of Antitussives and Expectorants.- 36. Screening methods involved in the evaluation of anti-diabetic drugs.- 37. Screening Methods for the Evaluation of Antithyroid Drugs.- 38. Screening methods for evaluation of antifertility drugs.- 39. Screening methods for evaluation of Posterior Pituitary, Adrenal Steroid, Testicular, Parathyroid, Ovarian, and Thyroid Hormones.- 40. Screening methods involved in the evaluation of drugs with analgesic, anti-inflammatory, and antipyretic activity.- 41. Screening Methods Involved in the Evaluation of Drugs with Ophthalmologic Activity.- 42. SCREENING METHODS FOR THE EVALUATION OF DRUGS AFFECTING PERIPHERAL NERVE FUNCTION.- 43. MUTAGENIC TOXICITY TESTING.- 44. Screening methods for evaluation of anticancer drugs.- 45. Screening Methods Involved in the Evaluation of Drugs for Benign Prostatic Hyperplasia.- 46. Evaluation of Drugs Acting on Autonomic Nervous System.- 47. Screening Methods for the Evaluation of Antifungal, Anthelminthic, Antibacterial, and Antiviral Agents.- 48. Preclinical toxicity studies.- 49. Ethical Issues in Animal Research.- 50. Good Laboratory Practice (GLP).- 51. Basic principles and applications of simple analytical methods.- 52. Principles of Quantitative Estimation of Drugs, Endogenous Compounds, and Poisons.- 53. Principles of quantitative estimation of drugs, endogenous compounds, and poisons - 2.- 54. Plant extraction methods.- 55. Literature search.- 56. STUDY DESIGNS.- 57. Ethical Issues Related to Medical Research on Human Participants.- 58. Basic principles and application of statistics in drug research.- 59. Calculation of Basic Statistical Parameters.- 60. Hypothesis Testing.- 61. Parametric tests.- 62. NON-PARAMETRIC TESTS.- 63. Common errors in using statistical tools and data presentation.

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Author Information

Dr. Mageshwaran Lakshmanan has completed his M.B.,B.S degree from Tuticorin Government Medical College (Affiliated to The Tamilnadu Dr. MGR Medical University) and M.D. Pharmacology from JIPMER, Puducherry, India. He is currently working as Senior Assistant Professor of Pharmacology at Thanjavur Medical College, Tamil Nadu, India and has 8 years of teaching experience. He is involved in research activities related to preclinical toxicity studies, drug interactions, and therapeutic drug monitoring. He is a member of the Pharmacovigilance Unit, the Institutional Ethical Committee and the Medical Education Unit of Thanjavur Medical College. In addition to his Departmental activities, he is also the Academic Officer In-Charge of Thanjavur Medical College. He manages undergraduate, postgraduate medical, and paramedical student admission and examinations, coordinates IEC, and acts as nodal officer of scholarship programs and ECFMG. He is well experienced in using various statistical tools and orients the postgraduates of all departments with the research methodology and bio-statistical concepts. He has many publications in various national and international journals. Dr. Deepak Gopal Shewade, is a retired Senior Professor of Pharmacology from JIPMER, Puducherry. He had joined as Assistant Professor in the same Institute in 1986. Earlier, he worked at BITS, Pilani for 7 years as faculty and completed his Ph. D. He did M. Pharm. (Pharmacology) from Nagpur University. His areas of interest are pharmacogenomics, rational drug therapy, analgesics, and GIT pharmacology. He has completed an Indo-French project under ICMR-INSERM on warfarin dose prediction based on genetic and environmental factors. He has more than 100 publications. He has guided 10 M.D. and 8 Ph. D. students. He has visited Thailand, Uganda, and France for academic and research purposes. In 2004, he was deputed to Uganda by the Ministry of External Affairs to start B. Pharm. course at MUST, Mbarara. As per Google Scholar, his h-index is 21 and i10-index is 35. Dr. Gerard Marshall Raj, holds an M.B.B.S. and M.D. in Pharmacology. Currently, he is working as an Assistant Professor in the Dept. of Pharmacology, All India Institute of Medical Sciences (AIIMS) Bibinagar, Hyderabad, Telangana, India. He has contributed and co-edited the books “Introduction to Basics of Pharmacology and Toxicology Volume 1: General and Molecular Pharmacology: Principles of Drug action” (Springer Nature; ISBN: 9789813297784) and “Introduction to Basics of Pharmacology and Toxicology Volume 2: Essentials of Systemic Pharmacology: From Principles to Practice” (Springer Nature; ISBN: 9789813360082). He has also contributed book chapters in other books. Currently, he is the Faculty In-Charge of Hospital Pharmacy and Hospital Management Information System (HMIS) at AIIMS, Bibinagar. He has received multiple prizes for academic and researchactivities – including the Dr. Peter Sleight Memorial Award for outstanding individual performance and Dr. Salim Yusuf Team Award for best team performance during a course on ‘Randomized Controlled Trials’ organized by St. John’s Medical College and Research Institute, recently. He has acted as a resource person in various workshops, training programs, CMEs, and delivered invited talks as a guest speaker. He was awarded the “Prof. M. N. Ghosh Gold Medal” for outstanding performance during the M.D. Pharmacology course at JIPMER, Puducherry, and has published many research articles, reviews, commentaries, case reports, and letters-to-the-editor in peer-reviewed and indexed journals. He has acted as a reviewer for several elite journals and also for the National Institute for Health Research (NIHR), UK – Global Health Research Unit and Groups Programme scrutinizing funding research proposals.

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