Overview

A current review of basic research on Rickettsiales biology and pathogenesis in one comprehensive volume. Details the scientific knowledge about how these obligate intracellular bacteria invade, survive and replicate inside eukaryotic cells. Describes the spectrum of disease caused by an infection including protective and pathologic immune responses. Describes the latest developments, including genomics and biomathematical modeling, and progress towards genetic tools and a vaccine. Serves as a significant research book for scientists, physicians, medical students, public health professionals, epidemiologists, biocomputational scientists and government policy makers. This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Full Product Details

Author:   Guy H Palmer ,  Abdu Azad
Publisher:   American Society for Microbiology
Imprint:   American Society for Microbiology
Dimensions:   Width: 18.00cm , Height: 2.50cm , Length: 25.60cm
Weight:   1.238kg
ISBN:  

9781555816773

ISBN 10:   1555816770
Pages:   458
Publication Date:   01 August 2012
Audience:   College/higher education ,  General/trade ,  Tertiary & Higher Education ,  General
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Table of Contents INTRACELLULAR PATHOGENS II: RICKETTSIALES CONTENTS 1. Clinical Disease: Current Treatment and New Challenges J. Stephen Dumler 1 2. Public Health: Rickettsial Infections and Epidemiology Jennifer H. McQuiston and Christopher D. Paddock 40 3. Phylogeny and Comparative Genomics: the Shifting Landscape in the Genomics Era Joseph J. Gillespie, Eric K. Nordberg, Abdu F. Azad, and Bruno W. S. Sobral 84 4. Invasion of the Mammalian Host: Early Events at the Cellular and Molecular Levels Juan J. Martinez 142 5. Establishing Intracellular Infection: Escape from the Phagosome and Intracellular Colonization (Rickettsiaceae) Matthew D. Welch, Shawna C. 0. Reed, and Cat M. Haglund 154 6. Establishing Intracellular Infection: Modulation of Host Cell Functions (Anaplasmataceae) Jason A. Carlyon 175 7. Rickettsial Physiology and Metabolism in the Face of Reductive Evolution Jonathon P. Audia 221 8. Innate Immune Response and Inflammation: Roles in Pathogenesis and Protection (Rickettsiaceae) Sanjeev K. Sahni, Elena Rydkina, and Patricia J. Simpson-Haidaris 243 9. Innate Immune Response and Inflammation: Roles in Pathogenesis and Protection (Anaplasmataceae) Nahed Ismail and Heather L. Stevenson 270 10. Adaptive Immune Responses to Infection and Opportunities for Vaccine Development (Rickettsiaceae) Gustavo Valbuena 304 11. Adaptive Immune Responses to Infection and Opportunities for Vaccine Development (Anaplasmataceae) Susan M. Noh and Wendy C. Brown 330 12. Persistence and Antigenic Variation Kelly A. Brayton 366 13. Transmission and the Determinants of Transmission Efficiency Shane M. Ceraul 391 14. The Way Forward: Improving Genetic Systems Ulrike G. Munderloh, Roderick F. Felsheim, Nicole Y. Burkhardt, Michael J. Herron, Adela S. Oliva Chavez, Curtis M. Nelson, and Timothy J. Kurtti 416

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