Overview

INTRODUCTION AND RATIONALE FOR INTRACELLULAR CHOLESTEROL TRAFFICKING This volume is an elaboration of an earlier small meeting held in St. Louis, Missouri. In April 1997, many of the authors met for a two-day meeting devoted entirely to intracellular cholesterol trafficking. The rationale for this meeting was that investigators interested in this topic worked in a variety of fields, and rarely, if ever, all met together. Everybody knew each other's papers but mostly worked in isolation from one another. Understanding of cholesterol trafficking also appeared to have reached the point where it would start to rapidly expand beyond these few laboratories. Understanding of cholesterol trafficking was moving from a largely descriptive science into the molecular age. It seemed a good time to get together and see how much we agreed upon up to this point. More authors contributed to this volume than attended the St. Louis meeting. That meeting was generously funded by grants from Bristol-Myers Squibb, Merck and Company and Parke-Davis, however, the total funding available limited the size of the meeting. For the book, we are not so limited and have tried to be as inclusive as possible and pretty much invited everyone who is presently active in this area. We were quite fortunate to successfully recruit the authors we sought for each of these chapters. The authors and their contributions can be organized by particular interests and particular areas of expertise.

Full Product Details

Author:   T.Y. Chang ,  Dale A. Freeman
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1998
Dimensions:   Width: 15.50cm , Height: 1.60cm , Length: 23.50cm
Weight:   0.474kg
ISBN:  

9781461373261

ISBN 10:   1461373263
Pages:   294
Publication Date:   13 October 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Regulation of ACAT and Intracellular Cholesterol Level.- The Sterol-Specific Regulation of ACAT-1 and SREBPs in Mammalian Cells and in Liver.- Intracellular Cholesterol Movement and Homeostasis.- Intracellular Sterol Esterification: Two Acyl CoA:Cholesterol Acyltransferases in Mammals.- Sterol Esterification and Homeostasis in a Model Eukaryote.- Niemann-Pick Type C Disease.- Cholesterol Distribution in Golgi, Lysosomes and Endoplasmic Reticulum.- Analysis of Somatic Cell Mutants That Express Defective Intracellular Cholesterol Transport.- What the Niemann-Pick Type C Gene Has Taught Us About Cholesterol Transport.- Cholesterol Transport in Specialized Cells.- The Movement of Plasma Membrane Cholesterol Through the Cell.- Cholesterol Trafficking in CACO-2 Cells.- Efflux and Plasma Transport of Biosynthetic Sterols.- Intramitochondrial Cholesterol Transfer in Steroidogenic Cells.- Mechanisms and Consequences of Cholesterol Loading in Macrophages.- Sterol Carrier Protein-2 and Cholesterol Transport Proteins.- Direct Evidence for Sterol Carrier Protein-2 (SCP-2) Participation in ACTH Stimulated Steroidogenesis in Isolated Adrenal Cells.- Intracellular Sterol Binding Proteins: Cholesterol Transport and Membrane Domains.- Functional Analysis of Sterol Carrier Protein-2 (SCP2) in the SCP2 Knockout Mouse.- Caveolae and Caveolin.- Scavenger Receptors, Caveolae, Caveolin, and Cholesterol Trafficking.- Selective Uptake of Lipoprotein-Free Cholesterol and Its Intracellular Transport — Role Of Caveolin.- Summary and Future Perspectives.

Reviews

`This book will be of undoubted value to those actively engaged in research on cholesterol transport. It would be a useful addition to most science libraries to allow consultation by those who wish greater knowledge on the topic but are not prepared to bear the cost of a personal copy.' James B.M. Rattray in Inform, 11 (2000)

'This book will be of undoubted value to those actively engaged in research on cholesterol transport. It would be a useful addition to most science libraries to allow consultation by those who wish greater knowledge on the topic but are not prepared to bear the cost of a personal copy.' James B.M. Rattray in Inform, 11 (2000)

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