Overview

Collectively, the chapters in this work should provide the reader with insight into the inter-relationships of the function of different organelles in the sequences of events that lead to cellular dysfunction and degeneration in the ageing human population. The chapters are rich in information for cell and molecular biologists pursuing studies of the different diseases covered. In addition, the clinician should find value in understanding mechanisms underlying age-related disease as such an understanding will lead to novel therapeutic approaches for an array of age-related diseases.

Full Product Details

Author:   M.P. Mattson (Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD, USA)
Publisher:   Elsevier Science & Technology
Imprint:   Elsevier Science Ltd
Volume:   v. 7
Dimensions:   Width: 15.60cm , Height: 1.90cm , Length: 23.40cm
Weight:   0.670kg
ISBN:  

9780444504951

ISBN 10:   0444504958
Pages:   284
Publication Date:   19 April 2001
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

Preface. Peroxisomal alterations in aging and age-related disease (J. Youssef, M. Badr). Perturbed calcium homeostasis in neurodegenerative disorders (M.P. Mattson). Mitochondrial dysfunction in diabetes mellitus (M.F. Bauer, S. Hofmann, K.-D. Gerbitz). Mitochondrial signaling and cancer (T.J. Preston, G. Singh). Molecular chaperones and age-related degenerative disorders (A.J.L. Macario, E. Conway de Macario). The role of telomerase in age-related degenerative disease and cancer (M. Fossel). Mitochondrial oxidative stress and metabolic alterations in neurodegenerative disorders (J.N. Keller, G.W. Glazner). Importance of proteasome-mediated proteolysis and alterations of the ubiquitin/proteasome pathway in cancer cells (V.J. Spataro, C.J. Norbury). Contributors' addresses.

Reviews

S.I.S. Rattan ...There are eight well-written chapters on a variety of age-related impairments and diseases. Biogerontology

S.I.S. Rattan ...There are eight well-written chapters on a variety of age-related impairments and diseases. Biogerontology

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