Overview

This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.

Full Product Details

Author:   Simon Fillatreau ,  Anne O'Garra
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 2014
Volume:   380
Dimensions:   Width: 15.50cm , Height: 1.30cm , Length: 23.50cm
Weight:   0.519kg
ISBN:  

9783662524053

ISBN 10:   3662524058
Pages:   238
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms. Karin R. Engelhardt and Bodo Grimbacher Control of intestinal inflammation by interleukin-10. Abhisake Kole and Kevin J. Maloy Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications. Maria Grazia Roncarolo, Silvia Gregori, Rosa Bacchetta and Manuela Battaglia. Interleukin-10-producing B cells and the regulation of immunity. Ellen Hilgenberg, Ping Shen, Van Duc Dang, Stefanie Ries, Imme Sakwa and Simon Fillatreau. Pathogen Manipulation of cIL-10 Signaling Pathways: Opportunities for Vaccine Development? Meghan K. Eberhardt and Peter A. Barry IL-10: achieving balance during persistent viral infection. Cherie T. Ng and Michael B.A. Oldstone The role of microRNAs in the control and mechanism of action of IL-10. Susan R. Quinn, Luke A. O’Neill The regulation of IL-10 expression. Leona Gabryšová, Ashleigh Howes, Margarida Saraiva and Anne O’Garra The Molecular Basis of IL-10 Function:  From Receptor Structure to the Onset of Signaling. Mark R. Walter Role of IL-22 in microbial host defense Celine Eidenschenk, Sascha Rutz, Oliver Liesenfeld, Wenjun Ouyang

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