Overview

Insulin: Deficiency, Excess and Resistance in Human Disease provides an overview of the role of insulin in the pathogenesis of prevalent non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, and cancer, along with a comprehensive review of insulin replacement therapies and novel cardioprotective and insulin-sensitizing drugs. Notable advances in precision diagnosis and therapy for single gene subtypes of diabetes in recent years are also discussed. The discovery of insulin and its lifesaving introduction into clinical practice is one of the most celebrated accomplishments of medical science. However, despite decades of progress and major technical advances, the goal of providing insulin replacement therapy that truly mimics normal physiology remains elusive.

Full Product Details

Author:   Andrew J. Krentz (Visiting Professor, Institute of Cardiovascular and Metabolic Research, University of Reading, UK)
Publisher:   Elsevier Science & Technology
Imprint:   Academic Press Inc
Weight:   0.900kg
ISBN:  

9780323917070

ISBN 10:   0323917070
Pages:   444
Publication Date:   22 January 2024
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Foreword by Steve Edelman Introduction and Preface by Andre J Krentz Section 1: Normal Physiology: Insulin Secretion and Insulin Action 1. Insulin Biosynthesis and Release by Gabriela da Silva Xavier 2. Classic Metabolic Actions of Insulin in Humans by Andrew J Krentz 3. Non-classic Effects of Insulin by George King Section 2a: Role of Insulin in Human Disease 4. Type 1 Diabetes Pathogenesis: Lessons Learned and Questions that Remain by Adebola Matthew Giwa, Abdel Hamad, Zahra Omidian, Angela Yang, Neha Majety, Tiffany Jackson, Kusuma Ananth, Mohanraj Sadasivam, Marjan Behzadirad, Thomas Donner and Rizwan Ahmed 5. Insulin Therapy – A Century of Progress by Geremia Bolli 6. Treatment and Prevention of Type 1 Diabetes in the 21st Century by Jay S Skylar, David Baidal, and J Sosenko 7. Differentiation of Diabetes by Pathophysiology: A Focus on Insulin Deficiency vs Insulin Resistance by Adrian Heald Section 2b: Syndromes of Insulin Excess 8. Congenital Hyperinsulinism by Katherine Lord and Diva D De Leon 9. Hypoglycemic Disorders in Adults by Adrian Vella and Maheswaran Dhanasekaran Section 2c: Insulin Resistance in Human Disease 10. Obesity and Insulin Resistance: Pathophysiology and Principles of Therapy by Rita Basu 11. The Cardiometabolic Syndrome and Vascular Disease: Pivotal Role of Insulin by Michael D Shapiro, Trevor Caldarera, and Jordan Tannenbaum 12. Insulin, IGF-1, and Cancer: Pathogenic Considerations and Therapeutic Opportunities by John Vincent Reynolds and Jessie Andrea Elliott 13. Insulin and Neurodegenerative Diseases by Heather A Ferris 14. Non-pharmacological, Pharmacological, and Surgical Options for Obesity-related Cardiometabolic Disorders: Metabolic and Clinical Impact by Alexander Dimitri Miras, Mariana Abdel-Malek, and Darmiga Thayabaran 15. Syndromes of Severe Insulin Resistance: Lessons from Nature by Andrew J Krentz

Reviews

*5 stars* ""...comprehensively covers the topic by first addressing the normal physiology of insulin, including biosynthesis, physiologic actions, and nonclassic actions. [Also] cover the role of insulin in diseases in states of excess and resistance, as well as treatment approaches.... [U]seful to all levels of learners including medical students, residents, fellows, and attending physicians as it provides an overview of insulin that would be beneficial to any level of medical learner.... [D]oes an excellent job of first giving a very in-depth overview of the basic biosynthesis and physiology of insulin - which provides the reader with the necessary basis to move forward into the pathophysiology chapters.... [U]ses frequent historical contexts and origin stories which were a nice way to engage by providing context.... [A]n excellent reference, especially for use when coming across patients with gray-area or complex diabetes."" --©Doody’s Review Service, 2024, Prathayini Subarajan, DO (Loyola University Stritch School of Medicine)

Author Information

Andrew Krentz has four decades of clinical and translational research experience in metabolic, endocrine and related cardiovascular disorders. His expertise in the life sciences includes preclinical and early-phase clinical drug development; he has personally contributed translational medical innovations to endocrinology clinical practice. He is actively involved in projects focused on precision diagnostics and therapeutics, digital healthcare, and healthy longevity that bridge the academic-industry spaces. Beyond his expertise in diabetes and endocrinology, he is accredited as a clinical specialist by the European Society for Hypertension and is a member of the Medical, Scientific & Research Committee of Heart UK. He is President-Elect of the Vascular, Lipid & Metabolism section of the Royal Society of Medicine as well as being a member of the European Group for the Study of Insulin Resistance (EGIR) and the Diabetes & Cardiovascular Study Group of the European Association for the Study of Diabetes (EASD). He has authored more than 200 scientific publications and founded the journal Cardiovascular Endocrinology & Metabolism and serves as Editor-in-Chief.

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