Overview

Understanding, identifying and influencing the biological systems are the primary objectives ofchemical biology. From this perspective, metal complexes have always been of great assistanceto chemical biologists, for example, in structural identification and purification of essentialbiomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic sideof chemical biology, which continues to receive considerable attention, is referred to as inorganicchemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensiveoverview of the current and emerging role of metal complexes in chemical biology. Throughout allof the chapters there is a strong emphasis on fundamental theoretical chemistry and experimentsthat have been carried out in living cells or organisms. Outlooks for the future applications ofmetal complexes in chemical biology are also discussed.Topics covered include: - Metal complexes as tools for structural biology- IMAC, AAS, XRF and MS as detection techniques for metals in chemical biology- Cell and organism imaging and probing DNA using metal and metal carbonyl complexes- Detection of metal ions, anions and small molecules using metal complexes- Photo-release of metal ions in living cells- Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well aschemical biologists working in both academia and industry.

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9781306684996

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