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OverviewTargeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins. Full Product DetailsAuthor: Fuyuhiko Tamanoi (Biochemist, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA) , Channing J. Der (University of North Carolina at Chapel Hill, Chapel Hill, USA)Publisher: Elsevier Science Publishing Co Inc Imprint: Academic Press Inc Volume: 34 Dimensions: Width: 15.20cm , Height: 2.00cm , Length: 22.90cm Weight: 0.570kg ISBN: 9780124201460ISBN 10: 0124201466 Pages: 280 Publication Date: 12 December 2013 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsDiscovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras•GTP-Effector Interaction Fumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka An Orthosteric Inhibitor of the RAS-SOS Interaction Seth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi Conformation-Specific Inhibitors of Raf kinases Xiaolun Wang and Kristin Schleicher Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant Cancers Leanna Gentry, Ahmed A. Samatar and Channing J. Der Inhibiting the RAS - PI3K Pathway in Cancer Therapy Clare Sheridan and Julian Downward The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras Cancers Jonathan M. Cooper, Brian O. Bodemann and Michael A. White p21-Activated Kinase Inhibitors Joachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions Fuyuhiko Tamanoi and Jie Lu Synthetic Lethal Genetic Screens in Ras Mutant Cancers Bing Yu and Ji LuoReviewsAuthor InformationFuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997. Tab Content 6Author Website:Countries AvailableAll regions |
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