Overview

Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.

Full Product Details

Author:   Fuyuhiko Tamanoi (Biochemist, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA) ,  Channing J. Der (University of North Carolina at Chapel Hill, Chapel Hill, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   34
Dimensions:   Width: 15.20cm , Height: 2.00cm , Length: 22.90cm
Weight:   0.570kg
ISBN:  

9780124201460

ISBN 10:   0124201466
Pages:   280
Publication Date:   12 December 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Discovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras•GTP-Effector Interaction Fumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka An Orthosteric Inhibitor of the RAS-SOS Interaction Seth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi Conformation-Specific Inhibitors of Raf kinases Xiaolun Wang and Kristin Schleicher Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant Cancers Leanna Gentry, Ahmed A. Samatar and Channing J. Der Inhibiting the RAS - PI3K Pathway in Cancer Therapy Clare Sheridan and Julian Downward The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras Cancers Jonathan M. Cooper, Brian O. Bodemann and Michael A. White p21-Activated Kinase Inhibitors Joachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions Fuyuhiko Tamanoi and Jie Lu Synthetic Lethal Genetic Screens in Ras Mutant Cancers Bing Yu and Ji Luo

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Author Information

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

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