Overview

This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.

Full Product Details

Author:   Fuyuhiko Tamanoi (Biochemist, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   33
Dimensions:   Width: 15.20cm , Height: 2.30cm , Length: 22.90cm
Weight:   0.710kg
ISBN:  

9780124167490

ISBN 10:   0124167497
Pages:   364
Publication Date:   30 September 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

The Ras superfamily G-proteins Fuyuhiko Tamanoi NMR Study to Identify a Ligand-Binding Pocket in Ras Till Maurer and Weiru Wang The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules Christian W. Johnson and Carla Mattos State 1(T) Inhibitors of Activated Ras Hans Robert Kalbitzer and Michael Spoerner Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras-Inhibitor Binding Interface  Alessandro Di Domizio and Francesco Peri Development of EHop-016, a Small Molecule Inhibitor of Rac Suranganie Dharmawardhane Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors Susanne Schmidt and Anne Debant Targeting the Dbl and Dock-Family RhoGEFs: a Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways Anne Blangy and Philippe Fort Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase Dominico Vigil and Channing J. Der A Two-Hybrid Approach to Identify Inhibitors of the RAS-RAF Interaction Vladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi and Erica A. Golemis Inhibitors of K-Ras Plasma Membrane Localization Kwang-jin Cho, Dharini van der Hoeven and John F. Hancock Ras Chaperons: New Targets for Cancer and Immunotherapy Yoel Kloog, Galit Elad-Sfadia, Roni Haklai and Adam Mor

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Author Information

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

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