Overview

During the last decade physical and chemical methods have improved rapidly - a fact which allowed the mode of action of antibiotics to be studied - and many biochemically-oriented scientists have devoted their research to the following questions: 1. What is the metabolic pathway that is inhibited selectively, and what are the target molecules within a sensitive cell? 2. What are the relationships between the chemical structure of an antibiotic and the physicochemical properties of the sensitive mole­ cule(s)? 3. Why and how far is the action selective? 4. Is it possible to correlate the interaction with the target mole­ cule(s) with the particular biological activities observed? This monograph deals with those antibiotics which interfere with the biosynthesis of nucleic acids. The idea was to provide an insight into how to investigate the preceding questions experimentally and to solve as yet unresolved problems rather than to give a review of the current state of knowledge. Although the biochemistry of nucleic acid synthesis is known in general, the precise molecular mechanisms by which deoxyribonucleic acid is replicated or transcribed has still to be clarified. For this reason it is not yet possible to describe the molecular mechanisms by which the inhibitors of nucleic acid and protein synthesis exhibit their effects. The fact that the inhibitors of nucleic acid and protein synthesis themselves served as useful tools to obtain an insight into the mechanisms of replication, transcription and translation was one of the most exciting discoveries in this field.

Full Product Details

Author:   H. Kersten ,  W. Kersten
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1974
Volume:   18
Dimensions:   Width: 17.00cm , Height: 1.00cm , Length: 24.40cm
Weight:   0.355kg
ISBN:  

9783642808579

ISBN 10:   3642808573
Pages:   186
Publication Date:   15 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

General Introduction.- I. Inhibitors of DNA Synthesis.- A. Mitomycin.- B. Streptonigrin.- C. Sibiromycin.- D. Phleomycin.- E. Bleomycin.- F. Neocarcinostatin.- G. Edeine.- H. Nalidixic Acid.- II. Inhibitors of RNA Synthesis that Interact with the DNA Template.- A. Actinomycin.- B. Anthracyclines.- C. Chromomycin, Olivomycin and Mithramycin.- D. Kanchanomycin.- E. Distamycin and Netropsin.- F. Anthramycin.- III. Inhibitors of RNA Synthesis Interacting with RNA Polymerases.- A. Rifamycins.- B. Streptovaricin.- C. Streptolydigin.- D. Amanitins.- IV. Inhibitors Interferring at the Precursor Level or with Regulatory Processes of Nucleic Acid Synthesis.- A. Nucleoside Antibiotics.- B. Mycophenolic Acid.- C. Amino Acid Analogs.- D. Quinone Antibiotics 1.- References.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions