Overview

This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals. 

Full Product Details

Author:   Michael B. A. Oldstone ,  Richard W. Compans
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   2015 ed.
Volume:   386
Dimensions:   Width: 15.50cm , Height: 2.70cm , Length: 23.50cm
Weight:   8.572kg
ISBN:  

9783319111575

ISBN 10:   3319111574
Pages:   484
Publication Date:   19 November 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Part I: Innate immunity   The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options John R. Teijaro   Innate immune sensing and response to influenza  Mohan S. Maddur and Bali Pulendran   The NS1 protein: a multitasking virulence factor  Juan Ayllon and Adolfo Garcia-Sastre   Role of NK cells in influenza infection  Stacey Shultz-Cherry   Host detection and the stealthy phenotype in influenza virus infection Pradyot Dash and Paul G. Thomas     Part II: Vaccines and adaptive immunity   Inactivated and adjuvanted influenza vaccines Giuseppe Del Giudice and Rino Rappuoli   Live attenuated influenza vaccine Hong Jin and Kanta Subbarao   Design of alternative live attenuated influenza virus vaccines Courtney Finch, Weizhong Li and Daniel R. Perez   Rapid production of synthetic influenza vaccines Philip R. Dormitzer   Influenza neuraminidase as a vaccine antigen Maryna C. Eichelberger and Hongquan Wan   Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin Florian Krammer, Peter Palese and John Steel   Structural characterization of epitopes recognized by broadly cross-reactive antibodies Peter S. Lee and Ian A. Wilson   Skin immunization with influenza vaccines Ioanna Skountzou and Richard W. Compans   Mucosal immunization and adjuvants  Hideki Hasegawa, Elly van Reit and Hiroshi Kida   B cell responses to infection and vaccination Christopher Chiu, Ali Ellebedy, Jens Wrammert and Rafi Ahmed   Memory CD4 T cells in influenza Kyra D. Zens and Donna L. Farber   The effector T cell response to influenza infection Matthew M. Hufford, Taeg S. Kim, Jie Sun and Thomas J. Braciale     Part III: New antiviral discovery  Antiviral Effects of Inhibiting Host Gene Expression  Ralph A. Tripp and S. Mark Tompkins  

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Author Information

Richard W. Compans is a Professor of Microbiology and Immunology and Scientific Director of Influenza Pathogenesis and Immunology Research Center, Emory University School of Medicine, Atlanta, GA, USA and series editor and volume editor of several successful volumes of Current Topics in Microbiology and Immunology. Michael B.A. Oldstone is a professor at the Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA and series editor and volume editor of several successful volumes of Current Topics in Microbiology and Immunology.

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