Overview

This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals. 

Full Product Details

Author:   Richard W. Compans ,  Michael B. A. Oldstone
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   2014 ed.
Volume:   385
Dimensions:   Width: 15.50cm , Height: 2.50cm , Length: 23.50cm
Weight:   7.981kg
ISBN:  

9783319111544

ISBN 10:   331911154
Pages:   444
Publication Date:   27 October 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

The Hemagglutinin - a Determinant of Pathogenicity.- Molecular determinants of pathogenicity in the polymerase complex.- Receptor binding properties of the influenza virus hemagglutinin as a determinant of host range.- Acid-induced membrane fusion by the hemagglutinin protein and its role in influenza virus biology.- Pandemic Preparedness and the Influenza Risk Assessment Tool (IRAT).- Avian influenza virus transmission to mammals.- Transmission in the Guinea Pig Model.- Enhancement of influenza virus transmission by gene reassortment.- Swine and Influenza: A Challenge to One Health Research.- Influenza Pathobiology and Pathogenesis in Avian Species.- Molecular determinants of influenza virus pathogenesis in mice.- Mammalian models for the study of H7 virus pathogenesis and transmission.- Pathogenesis and vaccination of influenza A virus in swine.- Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis.- Evolution and Ecology of Influenza A viruses.- Influenza A virus reassortment.- Antigenic Analyses of Highly Pathogenic Avian Influenza A Viruses.

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Author Information

Richard W. Compans is a Professor of Microbiology and Immunology and Scientific Director of Influenza Pathogenesis and Immunology Research Center, Emory University, School of Medicine, Atlanta, GA, USA and a series editor and volume editor of several volumes with Current Topics in Microbiology and Immunology. Michael B.A. Oldstone is a Professor at the Department of Immunology and Microbial Science at the Scripps Research Institute, La Jolla, CA, USA and a series editor and volume editor of several volumes with Current Topics in Microbiology and Immunology.

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