Overview

Recent advances in our understanding of the inflammatory process are reviewed in this multidisciplinary book. It presents the latest results from molecular biology, structural chemistry and fundamental biological and clinical investigations into inflammatory diseases, and discusses their implications for the development of novel therapeutic strategies. Written by international experts in the field, the chapters include contributions on the role of nitric oxide in inflammation and tissue destruction, cytokine networks in rheumatoid arthritis antigen specific therapies for the treatment of autoimmune diseases, and gene targeting for inflammatory cell adhesion molecules. All scientists involved in basic inflammation research in the pharmaceutical and biotechnology industries and academia should find this volume valuable to their work. The book is primarily intended for pharmacologists, pathologists, immunologists, chemists, and rheumatologists.

Full Product Details

Author:   Niall S. Doherty ,  Barry M. Weichmann ,  Douglas W. Morgan ,  Lisa A. Marshall
Publisher:   Birkhauser Verlag AG
Imprint:   Birkhauser Verlag AG
Volume:   v. 47
Weight:   0.650kg
ISBN:  

9783764351298

ISBN 10:   3764351292
Pages:   224
Publication Date:   27 March 1995
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

The pathogenesis of rheumatoid arthritis and the development of therapeutic strategies for the clinical investigation of biologics.- Immunoglobin gene expression in rheumatoid arthritis.- Cytokine networks in rheumatoid arthritis: Implications for therapy.- T cell receptor peptide vaccines as immunotherapy.- Antigen specific therapies for the treatment of autoimmune diseases.- Cytoplasmic transcription factors: Mediators of cytokine signaling.- Protein kinase C in cell signaling: Strategies for the development of selective inhibitors..- Regulation of ?1?6 integrin-mediated migration in macrophages.- Nitric oxide: What role does it play in inflammation and tissue destruction?.- Regulation of function and expression of P-selectin.- Regulation of L-selectin expression by membrane proximal proteolysis.- Transcriptional regulation of endothelial cell adhesion molecules: A dominant role for NF-?B.- Gene targeting for inflammatory cell adhesion molecules.- Site-directed mutagenesis - molecular biology and rational drug design.- C. Gordon Van Arman Scholarship Competition 7th International Conference of the Inflammation Research Association.- Workshop Sessions.- New animal models of inflammatory disease workshop.- Cell adhesion workshop.- Cartilage degradation and osteoarthritis workshop.- New drugs in phase I and beyond workshop.- Lymphocyte activation and immunoregulation workshop.- Lipid mediators: Mechanisms.- Inflammatory cytokines workshop.- Pulmonary inflammation workshop.- Nitric oxide poster discussion.- Poster discussion lipid mediators - new agents.

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