Overview

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.

Full Product Details

Author:   Randall E. Harris
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2007
Volume:   42
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   0.522kg
ISBN:  

9789048174294

ISBN 10:   9048174295
Pages:   324
Publication Date:   22 November 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Historical Perspectives.- Anti-Inflammatory Drugs in the 21st Century.- Inflammatory Mechanisms of Pathogenesis.- Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus.- Obesity, Inflammation, and Vascular Disease.- Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer.- Role of COX-2 in Inflammatory and Degenerative Brain Diseases.- Inflammation and Cardiovascular Disease: The Coxib Controversy.- Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors.- COX-2 Inhibitors And Cardiovascular Risk.- A Biological Rationale for the Cardiotoxic Effects of Rofecoxib.- Cox-2 Blockade in Cancer Prevention and Therapy.- Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade.- Strategies for Colon Cancer Prevention.- Inflammation and Neurodegenerative Disease.- NSAIDs for the Chemoprevention of Alzheimer’s Disease.- Inflammation in parkinson’s disease.- Nutrition, Inflammation and Chronic Disease.- Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases.- Nutritional Intervention in Brain Aging.

Reviews

From the reviews: This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition. ! Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. ! It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library. (Vladimir N. Despotovic, Doody's Review Service, February, 2010)

From the reviews: This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition. ... Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. ... It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library. (Vladimir N. Despotovic, Doody's Review Service, February, 2010)

From the reviews: This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition. ... Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. ... It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library. (Vladimir N. Despotovic, Doody,s Review Service, February, 2010)

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