Overview

The indications and results of isolated limb perfusion have varied over the years and are now mostly limited to unresectable melanoma and soft tissue sarcoma of the extremities. This thesis gives an overview of the current applications of isolated limb perfusion and answers a number of questions that have arisen regarding the practice of isolated limb perfusion. The principle aim of this thesis was to determine which patients should (or should not be) advised to undergo isolated limb perfusion, on the basis of 23 years of experience with isolated limb perfusion in the Antoni van Leeuwenhoek hospital/The Netherlands Cancer Institute and the Daniel den Hoed Cancer Center (Rotterdam). Secondly, the aim was to determine the most effective schedule and to describe the results that can be expected of isolated limb perfusion in terms of response, recurrence-free survival, overall survival and the long term quality of these patients' lives.

Full Product Details

Author:   Eva Noorda
Publisher:   Amsterdam University Press
Imprint:   Amsterdam University Press
Dimensions:   Width: 16.00cm , Height: 0.80cm , Length: 24.00cm
Weight:   0.280kg
ISBN:  

9789053566732

ISBN 10:   9053566732
Pages:   152
Publication Date:   20 January 2004
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Inactive
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

Table of Contents - 8[-]1. Introduction and outline of the thesis - 10[-]2. Isolated limb perfusion: what is the evidence for its use? - 18[-]3. Isolated limb perfusion for unresectable melanoma of the extremities - 32[-]4. Isolated limb perfusion prolongs the limb recurrence-free interval after several episodes of excisional surgery for locoregional recurrent melanoma - 44[-]5. Safety and efficacy of isolated limb perfusion in elderly melanomia patients - 58[-](Editorial) Isolated Limb Perfusion in Elderly Melanomia Patients - 70[-]6. Repeat isolated limb perfusion with TNFa and melphalan for recurrent limb melanoma after failure of previous perfusion - 72[-]7. Prognostic factors for poor survival after isolated limb perfusion: criteria for patient selection? - 84[-]8. Long-term results of a double perfusion schedule using high-dose hypertermia and melphalan sequentially in extensive melanoma of the lower limb - 94[-]9. Quality of life in long-term survivors of isolated limb perfusion for melanoma of the limbs - 104[-]10. Isolated limb perfusion with TNF-a and melphalan for unresectable soft tissue sarcoma of the extremities - 116[-]11. Isolated limb perfusion with melphalan for femoral metastases of breast cancer: case report - 128[-]12. Summary and conclusions/Samenvatting en conclusies - 134[-]Appendix.Regionale isolatieperfusie: ook bij bejaarde pati nten goed toepasbaar (Dutch) - 142[-]Dankwoord (Dutch) - 150[-]Curriculum Vitae (Dutch) - 153

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Author Information

Eva Noorda (1974) graduated from medical school ('arts-examen') in 2000, after which she worked for a year on the surgical ward of the Slotervaart hospital (Amsterdam). In the two following years, until July 2003, she worked at this thesis in the Antoni van Leeuwenhoek hospital/The Netherlands Cancer Institute (Amsterdam). From January 1st 2004 she is a resident in Surgery in the Slotervaart hospital and the VU Medical Center (Amsterdam).

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