Overview

Immunology is the most crowded and most actively traded sub-sector in biopharma. Every major indication - rheumatoid arthritis, psoriasis, inflammatory bowel disease, atopic dermatitis - has four to eight approved drugs and a pipeline of challengers. The catalysts are not binary in the traditional sense. They are comparative. The question is never just whether the drug works. It is whether it works better than adalimumab, ustekinumab, dupilumab, or the class leader that set the bar last cycle. This volume applies the BTH framework to inflammatory and autoimmune drug development. The Inflammation Path Tool scores six nodes, antigen presentation, innate activation, adaptive response, inflammatory cascade, autoimmunity loop, and intervention point, to determine how much information a catalyst will actually deliver and what the outcome distribution looks like before the data is unblinded. The MoA Tool covers every mechanism class in the sub-sector: anti-TNF, anti-IL, JAK inhibitors, T cell costimulation blockade, B cell depletion, CAR-T in autoimmune, tolerogenic vaccines, and selective cytokine modulators. The Catalyst Stack maps twenty catalyst types, from Phase 1 through biosimilar entry and label expansion, with IV expansion and crush figures calibrated to the immunology timeline. The Trade Setup chapter delivers eight named structures built for the head-to-head trial environment, the AdCom, the PDUFA, and the long-cycle franchise catalyst. Immunology rewards the trader who understands the class, not just the drug. This book connects the Biology to the trade! In the series: Book 1: Oncology Book 2: Immunology & Autoimmune Book 3: Neuroscience Book 4: Rare Disease & Orphan Drugs Book 5: Cardiovascular Book 6: Metabolic Disease & Endocrinology Book 7: Gene Therapy & RNA Therapeutics Book 8: Infectious Disease & Vaccines

Full Product Details

9798197416247

Table of Contents

Reviews

Author Information

Tab Content 6

Countries Available