Overview

This book reviews the role of each cell subset in the skin, providing the basics for understanding skin immunology and the mechanisms of skin diseases. The skin is one of the immune organs and is continually exposed to foreign antigens and external stimuli that must be monitored and characterized for possible elimination. Upon exposure to foreign antigens, the skin can elicit a variety of immune responses in harmony with skin components that include keratinocytes, dendritic cell subsets, mast cells, basophils, fibroblasts, macrophages, gamma-delta T cells, neutrophils, myeloid-derived suppressor cells, vascular and lymphatic cells, hair follicles, platelets, and adipose tissues, among others. In the past 10 years, knowledge of immunology has expanded drastically in areas such as innate immunity (Toll-like receptors, C-type lectins), and host defenses to bacteria and viruses, and this increased knowledge has led to the development of more effective treatment of psoriasis and other skin diseases. This book provides updates on the mechanisms of skin diseases including contact dermatitis, atopic dermatitis, psoriasis, urticaria, drug eruption, bullous diseases, anaphylaxis, graft-versus-host disease, rosacea, lymphoma, photodermatology, and collagen vascular diseases. Understanding the basics of skin immunology will help clinicians and dermatologists use new therapeutics such as biologics efficiently. Serving as an intermediary between basic science and clinical medicine, this book gives readers the opportunity to understand and marvel at the mystery and fascination of skin immunology.

Full Product Details

Author:   Kenji Kabashima
Publisher:   Springer Verlag, Japan
Imprint:   Springer Verlag, Japan
Edition:   Softcover reprint of the original 1st ed. 2016
Weight:   8.727kg
ISBN:  

9784431567127

ISBN 10:   4431567127
Pages:   510
Publication Date:   25 April 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface.- 1 Overview: Immunology of the skin.- Part 1 Components of Skin Immune Cells.- 2 Stratum Corneum.- 3 Keratinocytes.- 4 Langerhans cells and dermal dendritic cells.- 5 T cells.- 6 gd T cells.- 7 B cells.- 8 Mast cells and basophils .- 9 Neutrophil .- 10 Macrophages.- 11 Myeloid derived suppressor cells.- 12 Lymphatic vessels.- 13 Hair follicles.- 14 Platelets.- 15 Adipose tissues.- Part 2 Immune Systems in the Skin.- 16 Innate immunity.- 17 C-type lectin receptors.- 18 Emergence of virulent Staphylococci overriding innate immunity of skin in community.- 19 Viral infection.- 20 Contact dermatitis.- 21 Atopic dermatitis: Common extrinsic and enigmatic intrinsic types.- 22 Psoriasis.- 23 Urticaria.- 24 Cutaneous adverse drug reactions: Stevens-Johnson syndrome and toxic epidermal necrolysis.- 25 Pemphigus .- 26 Anaphylaxis.- 27 Graft Versus Host Disease (GVHD).- 28 Rosacea in skin innate immunity.- 29 Cutaneous Lymphomas.- 30 Photodermatology- Therapeutic photomedicine for skindiseases.- 31 Collagen vascular disease.- Index.

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Author Information

Kenji Kabashima MD, PhD. Department of Dermatology Kyoto University Graduate School of Medicine 54 Shogoin-Kawara, Sakyo, Kyoto 606-8507, Japan TEL +81-75-751-3310 FAX +81-75-761-3002 E-mail kaba@kuhp.kyoto-u.ac.jp

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