Overview

The history of mankind has been shaped by infections, more than by war and famine together. At the same time, however, the development of society has had an equally important effect on human diseases. The emergence of agriculture, urban societies and high population densities has been proven to be crucial for the spread of pathogens, and thus human action is currently the single most important driver of infectious epidemiology. Even today, where once major killers such as poliomyelitis have been eradicated, new pathogens are appearing as result of human activity. One such group of pathogens are the fungi, whose emergence is mainly due to modern medical practices. Fungal microorganisms, from yeasts colonizing the skin or mucosa, to molds from soil or water, are usually harmless in the context of normal host responses. However, the success of chemotherapy, as well as the AIDS pandemia, has led to immune deficiencies in a significant segment of the patient population, and the extensive use of intravenous catheters has provided a way of access for microorganisms which otherwise would find difficult to infect the host. As a result, a yeast such as Candida is now on the 4th place on the list of the most frequent sepsis agents, whereas infection with the mold Aspergillus is increasing in incidence and it is one of the most feared complications in patients with hematological malignancies.

Full Product Details

Author:   Gordon D. Brown ,  Mihai G. Netea
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2007
Dimensions:   Width: 15.50cm , Height: 2.60cm , Length: 23.50cm
Weight:   0.777kg
ISBN:  

9789048173808

ISBN 10:   9048173809
Pages:   492
Publication Date:   10 November 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Preface Section 1: Cells chapter 1: Macrophages Sigrid E.M. Heinsbroek and Siamon Gordon; University of Oxford chapter 2: Dendritic cells Luigina Romani; University of Perugia chapter 3: The neutrophil David H. Dockrell, Emmet E. McGrath, Moira KB Whyte, and Ian Sabroe; University of Sheffield chapter 4: Lymphocytes Anna Vecchiarelli, Antonella Mencacci, Francesco Bistoni ; University of Perugia chapter 5: Other cells: The role of non-neutrophilic granulocytes, NK and NKT cells in fungal immunology Jeremy CD Wiseman and Christopher H. Mody; University of Calgary chapter 6: Genes and gene pathways in Candida Infection Robert B. Ashman, Camile S. Fara, and Christine Wells; University of Queensland and Griffith University Section 2: Soluble factors chapter 7: Collectins and pentraxins Uday Kishore and Ken Reid; University of Oxford and Justus-Liebig-University chapter 8: Complement in fungal infections and complement evasion strategies Cornelia Speth, Cornelia Lass-Flörl and Reinhard Würzner; Innsbruck Medical University and Ludwig-Boltzmann-Institute of AIDS Research. chapter 9: Cytokines Karen F. Buckland and Cory M. Hogaboam; University of Michigan Medical School. chapter 10: Antibodies Josè Lòpez-Ribot, Rosalìa Dìez-Orejas and Concha Gil ; The University of Texas at San Antonio and Complutense University Section 3: Non-Opsonic Fungal Receptors chapter 11: The recognition of fungal pathogens by Toll-like receptors Mihai G. Netea, Jos WM Van der Meer, Bart Jan Kullberg; Radboud University Nijmegen Medical Center and Nijmegen University Center for Infectious Diseases chapter 12: Fungal ß-glucans and their receptors S Vicky Tsoni and Gordon D Brown; University of Cape Town chapter 13: Detection of fungi by mannose-basedrecognition receptors F Meyer-Wentrup, A Cambi, CG Figdor and GJ Adema; Radboud University Nijmegen Medical Center Section 4: Immunity to specific pathogens chapter 14: Pneumocystis Laura McKinley and Chad Steele, University of Pittsburgh School of Medicine chapter 15: Interactions of Aspergillus fumigatus with its host during invasive pulmonary infections Jean-Paul Latgé and Anne Beauvais; Pasteur Institute chapter 16: C. albicans and C. glabrata Desa Lilic and Ken Haynes, School of Clinial Medicines, Newcastle University and Department of INfectious diseases, Imerpial College London chapter 17: Immunology of infections with Cryptococcus neoformans Pauline Ellerbroek, Anna Vecchiarelli, Andy Hoepelman and Frank Coenjaerts; University Medical Center and University of Perugia. chapter 18: Histoplasma capsulatum Joshua D Nosanchuk; Albert Einstein College of Medicine Section 5 chapter 19: Escape mechanisms from the immune response David M. Underhill; Cedars-Sinai Medical Center Section 6: Immune-based therapeutic strategies chapter 20: Cytokine treatment of fungal infections Bart-Jan Kullberg; Radboud University Nijmegen Medical Center chapter 21: Fungal vaccines and vaccination: problems and perspectives Antonio Cassone; Istituto Superiore di Santià Index

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