Overview

Immunology: A Short Course, 7th Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs. This new edition of Immunology: A Short Course: • Has been fully revised and updated, with a brand new art program to help reinforce learning • Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area • Highlights important therapeutic successes resulting from targeted antibody therapies • Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical applications

Full Product Details

Author:   Richard Coico ,  Geoffrey Sunshine
Publisher:   John Wiley and Sons Ltd
Imprint:   Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)
Edition:   7th Edition
Dimensions:   Width: 21.70cm , Height: 2.00cm , Length: 27.60cm
Weight:   1.222kg
ISBN:  

9781118396919

ISBN 10:   111839691
Pages:   432
Publication Date:   24 April 2015
Audience:   College/higher education ,  Undergraduate
Replaced By:   9781119551577
Format:   Paperback
Publisher's Status:   Active
Availability:   In stock  
We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately.

Table of Contents

About the Authors xv Contributors xvi Preface and Acknowledgments xvii How to Use Your Textbook xix About the Companion Website xxiii 1 Overview of the Immune System 1 Introduction 1 Innate and Adaptive Immunity 2 Clonal Selection Theory 3 Active, Passive, and Adoptive Immunization 5 Humoral and Cellular Immunity 6 Cell-Mediated Immunity 7 Generation of Diversity in the Immune Response 8 Benefits of Immunology 8 Damaging Effects of the Immune Response 9 The Future of Immunology 9 The Short Course Begins Here 10 References and Bibliography 10 2 Innate Immunity 11 Introduction 11 Physical and Chemical Barriers of Innate Immunity 11 Pattern Recognition: The Hallmark of Innate Immune Responses 15 Complement 18 Inflammation 20 References and Bibliography 24 Review Questions 24 Answers to Review Questions 25 3 Adaptive Immunity 26 Cells and Organs Involved in Adaptive Immunity 26 The Fate of Antigen after Penetration 31 Interrelationship between Innate and Adaptive Immunity 33 Review Questions 34 Answers to Review Questions 34 4 Immunogens and Antigens 35 Introduction 35 Requirements for Immunogenicity 35 Primary and Secondary Responses 38 Antigenicity and Antigen-Binding Site 38 Epitopes Recognized by B Cells and T Cells 39 Major Classes of Antigens 40 Binding of Antigen with Antigen-Specific Antibodies or T Cells 41 Cross-Reactivity 41 Adjuvants 42 References and Bibliography 44 Review Questions 45 Answers to Review Questions 45 5 Antibody Structure and Function 47 Introduction 47 Isolation and Characterization of Immunoglobulins 48 Structure of Light and Heavy Chains 48 Domains 51 Hinge Region 51 Variable Region 51 Immunoglobulin Variants 53 Structural Features of IgG 55 Structural Features of IgM 59 Biologic Properties of IgM 59 Structural and Biologic Properties of IgA 60 Structural and Biologic Properties of IgD 61 Structural and Biologic Properties of IgE 62 Kinetics of the Antibody Response Following The Immunoglobulin Superfamily 63 References and Bibliography 65 Review Questions 65 Answers to Review Questions 66 6 Antigen–Antibody Interactions, Immune Assays, and Experimental Systems 67 Introduction 67 Antigen–Antibody Interactions 67 Primary Interactions between Antibody and Antigen 68 Secondary Interactions between Antibody and Immunoassays 74 Immunofluorescence 76 Flow Cytometry 76 Immunoabsorption and Immunoadsorption 78 Cellular Assays 78 Cell Culture 79 Experimental Animal Models 81 Transgenic Mice and Gene Targeting 82 Analysis of Gene Expression 83 References and Bibliography 85 Review Questions 86 Answers to Review Questions 86 7 The Genetic Basis of Antibodystructure 88 Introduction 88 A Brief Review of Nonimmunoglobulin Gene Structure and Gene Expression 88 Genetic Events in Synthesis of Ig Chains 90 Class or Isotype Switching 94 Generation of Antibody Diversity 95 Role of Activation-Induced Cytidine Deaminase in Generating Antibody Diversity 96 References and Bibliography 98 Review Questions 98 Answers to Review Questions 99 8 Biology of the B Lymphocyte 100 Introduction 100 Development of B Lymphocytes 100 Sites of Antibody Synthesis 105 B-Cell Membrane Proteins 110 References and Bibliography 115 Review Questions 116 Answers to Review Questions 116 9 How T Cells Recognize Antigen: The Role of the Major Histocompatibility Complex 117 Introduction 117 How the MHC Got Its Name 117 MHC Role in Antigen Presentation 118 Different MHC Molecules Are Expressed by Distinct Variability of MHC Class I and MHC Class II Molecules 119 Structure of MHC Class I and Class II Molecules 120 Antigen Processing and Presentation: How MHC Other Types of Antigen That Activate T-Cell Responses 129 Genes of the HLA Region 130 Nomenclature of Polymorphic MHC Molecules 131 Regulation of Expression of MHC Genes 131 MHC in Other Species 132 Diversity of MHC Molecules: MHC Association with Resistance and Susceptibility to Disease 132 References and Bibliography 135 Review Questions 135 Answers to Review Questions 136 10 Biology of the T Lymphocyte 137 Introduction 137 The Antigen-Specific T-Cell Receptor 137 Genes Coding for T-Cell Receptors 143 Generation of T-Cell Receptor Diversity 144 T-Cell Differentiation in the Thymus 144 References and Bibliography 151 Review Questions 151 Answers to Review Questions 152 11 Activation and Function of T Cells 153 Introduction 153 A Two-Signal Model for the Activation of T Cells 153 Dendritic Cells Are the Key APC for Naïve T Cells 153 Activation of CD4+ T Cells 155 CD4+ T-Cell Function 160 Activation and Function of CD8+ T Cells 168 CD8+ T-Cell Killing of Target Cells 169 Memory T Cells 171 Function of Other Subsets of T Cells 171 References and Bibliography 174 Review Questions 174 Answers to Review Questions 175 12 Cytokines 176 Introduction 176 The History of Cytokines 176 General Properties of Cytokines 177 Functional Categories of Cytokines 179 Cytokine Receptors 185 Cytokine Receptor-Mediated Signal Transduction 186 Role of Cytokines and Cytokine Receptors in Therapeutic Exploitation of Cytokines and Cytokine Receptors 189 References and Bibliography 192 Review Questions 192 Answers to Review Questions 193 13 Tolerance and Autoimmunity 194 Introduction 194 Central Tolerance 195 Peripheral Tolerance 197 Oral Tolerance 200 Immune Privilege 201 Autoimmunity and Disease 201 Autoimmune Diseases 205 References and Bibliography 214 Review Questions 215 Answers to Review Questions 216 14 Complement 217 Introduction 217 Overview of Complement Activation 217 Regulation of Complement Activity 222 Biologic Activities of Complement 224 Complement Deficiencies 228 References and Bibliography 230 Review Questions 231 Answers to Review Questions 231 15 Hypersensitivity: Type I 233 Introduction 233 General Characteristics of Allergic Reactions 234 Sensitization Phase 234 Activation Phase 235 Effector Phase 237 Clinical Aspects of Allergic Reactions 240 Clinical Tests for Allergies and Clinical Intervention 242 Intervention 242 The Protective Role of IgE 244 References and Bibliography 246 Review Questions 246 Answers to Review Questions 247 16 Hypersensitivity: Types II and III 249 Introduction 249 Type II Hypersensitivity 249 Examples of Type II Hypersensitivity Reactions 251 References and Bibliography 257 Review Questions 257 Answers to Review Questions 258 17 Hypersensitivity: Type IV 259 Introduction 259 General Characteristics and Pathophysiology of Examples of DTH 261 Treatment of DTH 264 References and Bibliography 265 Review Questions 266 Answers to Review Questions 266 18 Immunodeficiency Disorders and Neoplasias of the Lymphoid System 268 Introduction 268 Immunodeficiency Syndromes 269 Acquired Immunodeficiency Syndrome 282 Neoplasms of Lymphoid System 287 References and Bibliography 294 Review Questions 295 Answers to Review Questions 296 19 Transplantation 298 Introduction 298 Relationship between Donor and Recipient 298 Immune Mechanisms Are Responsible for Allograft Rejection 300 Categories of Allograft Rejection 300 Role of MHC Molecules in Allograft Rejection 301 Role of T Cell Lineages and Cytokines in Allograft Rejection 302 Laboratory Tests Used in Tissue Typing 303 Prolongation of Allograft Survival: Immunosuppresive Therapy 304 Hematopoietic Stem Cell Transplantation 307 Graft-versus-Host Disease 308 Xenogeneic Transplantation 308 The Fetus: A Tolerated Allograft 309 References and Bibliography 310 Review Questions 310 Answers to Review Questions 311 20 Tumor Immunology 312 Introduction 312 Tumor Antigens 312 Categories of Tumor Antigens 313 Immunologic Factors Influencing the Incidence of Cancer 315 Effector Mechanisms in Tumor Immunity 316 Cell-Mediated Responses to Tumor Cells 318 Cytokines 319 Limitations of the Effectiveness of the Immune Response against Tumors 320 Immunodiagnosis 320 Tumor Immunoprophylaxis 321 Immunotherapy 322 References and Bibliography 326 Review Questions 326 Answers to Review Questions 327 21 Resistance and Immunization to Infectious Diseases 328 Introduction 328 Host Defense against the Various Classes of Microbial Pathogens 330 Mechanisms by Which Pathogens Evade the Immune Response 334 Principles of Immunization 336 Objectives of Immunization 337 Active Immunizations 337 Basic Mechanisms of Protection 339 Vaccine Precautions 341 Recent Approaches to Production of Vaccines 342 Passive Immunization 344 References and Bibliography 348 Review Questions 349 Answers to Review Questions 350 Glossary 351 Appendix: Partial List of CD Antigens 378 Index 381

Reviews

Immunology: A Short Course, Seventh Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs.This new edition of Immunology: A Short Course:* Has been fully revised and updated, with a brand new art program to help reinforce learning* Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area* Highlights important therapeutic successes resulting from targeted antibody therapies* Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical application. (Journal Investigative Allergol Clinical Immunology, Vol. 26 (1))

Immunology: A Short Course, Seventh Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs. This new edition of Immunology: A Short Course: Has been fully revised and updated, with a brand new art program to help reinforce learning Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area Highlights important therapeutic successes resulting from targeted antibody therapies Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical application. ( Journal Investigative Allergol Clinical Immunology, Vol. 26 (1))

Author Information

Richard Coico, SUNY Downstate College of Medicine, Brooklyn, New York Geoffrey Sunshine, Heath Effects Institute, and Tufts University School of Medicine, Boston, Massachusetts

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions