Overview

Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.

Full Product Details

Author:   Eric Vivier ,  Marco Colonna
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2006 ed.
Volume:   298
Dimensions:   Width: 15.50cm , Height: 1.70cm , Length: 23.50cm
Weight:   1.290kg
ISBN:  

9783540260837

ISBN 10:   3540260838
Pages:   284
Publication Date:   20 October 2005
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Strategies of Natural Killer Cell Recognition and Signaling.- Signal Transduction in Natural Killer Cells.- Transcriptional Regulation of NK Cell Receptors.- Extending Missing-Self? Functional Interactions Between Lectin-like Nkrp1 Receptors on NK Cells with Lectin-like Ligands.- The CD2 Family of Natural Killer Cell Receptors.- Immunobiology of Human NKG2D and Its Ligands.- NKG2 Receptor-Mediated Regulation of Effector CTL Functions in the Human Tissue Microenvironment.- Dendritic Cell-NK Cell Cross-Talk: Regulation and Physiopathology.- NK Cell Activating Receptors and Tumor Recognition in Humans.- NK Cell Recognition of Mouse Cytomegalovirus-Infected Cells.- NK Cell Receptors Involved in the Response to Human Cytomegalovirus Infection.- The Impact of Variation at the KIR Gene Cluster on Human Disease.- NK Cells in Autoimmune Disease.

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