Overview

The developing brain is exquisitely sensitive to both endogenous and exogenous signals which direct or significantly alter the developmental trajectory of cells, neural circuits, and associated behavioral outcomes for the life of the individual. Contrary to initial dogma that the brain is one of the few organs within the body that is immune-privileged, evidence indicates that the immune system has a critical role in brain function during development as well as during sickness and health in adulthood. Microglia are the primary immune cells within the brain, and they are in constant communication with the peripheral immune system and surrounding cell types within the brain. We describe the important role of the immune system, including microglia, during brain development, and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition. Growing evidence indicates that there is a strong link between many neuropsychiatric disorders and immune dysfunction, with a distinct etiology in neurodevelopment. Thus, understanding the role of the immune system and immune activation during the critical period of brain development is a necessary step toward understanding the potential origins of these devastating disorders.

Full Product Details

Author:   Jaclyn Schwarz ,  Staci D. Bilbo
Publisher:   Morgan & Claypool Publishers
Imprint:   Morgan & Claypool Publishers
Dimensions:   Width: 18.70cm , Height: 0.70cm , Length: 23.50cm
Weight:   0.238kg
ISBN:  

9781615043514

ISBN 10:   1615043519
Pages:   128
Publication Date:   30 December 2010
Audience:   General/trade ,  General
Format:   Paperback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Introduction The Immune Response Brain-Immune Communication Microglia Are Immune Cells of the Brain The Functional Role of Microglia and Immune Molecules in Neurodevelopment Early-Life Programming of Brain and Behavior: A Critical Role for the Immune System Commonly Used Models of Early Life Immune Activation in the Rodent Early Life Immune Activation and Cognitive Impairment in Adulthood Mechanisms Underlying the Enduring Changes in Neuroimmune Function Caused by Early Life Infection Toll-Like Receptors and Immune Activation During Early Brain Development Environmental Triggers of TLR Activation: Long-Term Programming of Brain and Behavior Future Directions to Understanding Immune Function and Brain Development References

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